Anti-KLHL15 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

KLHL15 also known as Kelch-like protein 15 plays an important role in cellular protein dynamics. KLHL15 functions as a substrate-specific adaptor for a Cullin-RING E3 ubiquitin ligase complex which tags proteins for degradation. The mass of KLHL15 is approximately 65 kDa. It is mainly expressed in the central nervous system and several other tissues with varied expression levels across different cell types.

Biological function summary

KLHL15 influences diverse cellular processes through its regulatory role. Acting as part of the ubiquitination machinery KLHL15 aids in maintaining protein homeostasis by targeting specific proteins for ubiquitin-mediated proteasomal degradation. KLHL15 forms part of a complex including Cullin3 and a RING-box protein contributing to protein ubiquitination. This protein interaction ensures proper cellular function by regulating protein turnover.

Pathways

KLHL15 is involved in significant cellular pathways like the ubiquitin-proteasome system and the Wnt signaling pathway. These pathways are important for controlling protein stability and transmitting cell signals. In these pathways KLHL15 interacts with proteins like Cullin3 which are essential for tagging unwanted proteins for elimination thereby affecting various cellular processes.

Associated diseases and disorders

KLHL15 has associations with neurological diseases and certain types of cancer. In the context of neurodegenerative diseases KLHL15 interacts with proteins such as Cullin3 which are involved in protein degradation pathways impacting disease outcomes. Furthermore alterations in the levels or function of KLHL15 might contribute to the development of specific cancers by disrupting normal protein regulation processes.