Rabbit Polyclonal KLHL32 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human KLHL32 aa 200-300.
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BKLHD5, KIAA1900, KLHL32, Kelch-like protein 32, BTB and kelch domain-containing protein 5
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLHL32 antibody (AB243805)
Formalin-fixed, paraffin-embedded human cerebral cortex tissue stained for KLHL32 using ab243805 at 1/200 dilution in immunohistochemical analysis.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLHL32 antibody (AB243805)
Formalin-fixed, paraffin-embedded human tonsil tissue stained for KLHL32 using ab243805 at 1/200 dilution in immunohistochemical analysis. Low expression, as expected.
Reactivity data
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Biological function summary
KLHL32 associates with the regulation of protein degradation impacting cellular homeostasis and response to stress. This protein forms part of the complex networks involved in targeting specific substrates for ubiquitination. By promoting protein turnover KLHL32 influences various cellular processes notably including cell cycle progression and signal transduction. The protein's ability to guide ubiquitin-mediated proteolysis highlights its involvement in maintaining a balance between protein synthesis and degradation.
Pathways
KLHL32 participates in the ubiquitin-proteasome system and relates to the signaling pathways involved in cell cycle control and apoptosis. Its interaction with proteins such as Cullin-3 in the E3 ligase complex positions KLHL32 as an influencer of cellular growth and differentiation processes. This connection positions KLHL32 within essential pathways including the regulation of NF-kB signaling and the MAPK signaling pathways highlighting its role in cellular response mechanisms to stress and DNA damage.
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