Anti-KLLN antibody [EPR16934]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

KLLN also known as Killin is a DNA-binding protein approximately 19 kDa in size. It is expressed mainly in the nucleus of cells. KLLN plays a role in DNA replication inhibition and is involved in apoptosis. Its expression level may vary among different tissues with a reported presence in the thymus spleen and bone marrow. The connection of KLLN to certain cellular processes highlights its significance for maintaining cellular homeostasis and regulating cell growth.

Biological function summary

Killin functions as a direct inhibitor of DNA synthesis. It interacts with components involved in cell cycle control serving as a putative tumor suppressor. Killin can form part of larger protein complexes influencing the DNA damage response by mediating G1 arrest which is critical to prevent uncontrolled cell division. This protein exerts its effects by managing the balance between cell proliferation and programmed cell death making it a point of interest for researchers studying carcinogenesis mechanisms.

Pathways

We observe that Killin integrates into the p53 signaling pathway an important pathway in the regulation of cell growth and apoptosis. It is closely associated with proteins like p53 and PTEN. The KLLN gene lies adjacent to PTEN and these proteins often co-regulate each other’s activity impacting key cellular events such as stress response and DNA damage repair. This alignment with the p53 and PTEN pathways highlights Killin's role in maintaining genomic integrity and cellular responses to damage.

Associated diseases and disorders

Killin displays a notable connection with certain cancers and neurodegenerative disorders. Alterations in its expression or mutations can influence the development of prostate cancer with its role as a tumor suppressor directly impacting cellular proliferation pathways. Additionally KLLN’s interaction with PTEN links it to the genetic disorder Cowden syndrome which features increased cancer risk and skin lesions. Understanding KLLN's involvement with these diseases offers insight into potential therapeutic targets and new strategies for treatment interventions.