Anti-KPNA5 antibody

Supplementary info

Activity summary

The protein KPNA5 also known as importin alpha 5 belongs to the karyopherin alpha family. Mechanically it plays an important role in the nuclear import of proteins by recognizing and binding to nuclear localization signals (NLS) on cargo proteins. Importin alpha 5 acts as an adaptor bridging cargo proteins with importin beta which facilitates transport through the nuclear pore complex. KPNA5 has a molecular mass of approximately 60 kDa and is expressed in a wide range of tissues including the brain heart and pancreas indicating its involvement in various cellular processes.

Biological function summary

KPNA5 is important in the transportation of proteins across the nuclear envelope a process that regulates many cellular functions such as cell division signal transduction and transcriptional control. KPNA5 as part of the importin alpha/beta complex regulates the import of proteins like transcription factors and tumor suppressors into the nucleus. The efficient functioning of this complex ensures proper cellular responses and maintenance of cellular homeostasis. By controlling the nuclear-cytoplasmic transport KPNA5 facilitates the precise localization of proteins necessary for normal cell function.

Pathways

KPNA5 is involved in the nuclear transport pathway and is closely associated with the nucleocytoplasmic transport pathway. It interacts with proteins such as importin beta1 for translocation through the nuclear pore complex. This interaction is essential for processes like the regulation of gene expression and signal-dependent nuclear import which are critical for maintaining cellular activities and responses. The precise regulation of these pathways ensures that cells respond appropriately to different physiological signals and stresses.

Associated diseases and disorders

KPNA5 shows a connection to certain cancers and neurodegenerative diseases. Its role in nuclear-cytoplasmic transport can influence oncogenesis as disruption in the import of cancer-related proteins could lead to tumor progression. Additionally abnormal KPNA5 function may associate with neurodegenerative conditions where impaired protein transport affects neuronal health. In such disorders KPNA5 often interacts with tumor suppressor proteins and other proteins that are important for neuronal function illustrating its potential as a target for therapeutic intervention.