JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB105350

Anti-KPNA6 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal KPNA6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KPNA6.

View Alternative Names

IPOA7, KPNA6, Importin subunit alpha-7, Karyopherin subunit alpha-6

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-KPNA6 antibody (AB105350)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-KPNA6 antibody (AB105350)

Immunofluorescence of KPNA6 in 293 cells with ab105350 at 20 ug/mL.

Immunocytochemistry/ Immunofluorescence - Anti-KPNA6 antibody (AB105350)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-KPNA6 antibody (AB105350)

Immunofluorescence of KPNA6 in 293 cells using ab105350 at 20 ug/ml.

Western blot - Anti-KPNA6 antibody (AB105350)
  • WB

Unknown

Western blot - Anti-KPNA6 antibody (AB105350)

All lanes:

Western blot - Anti-KPNA6 antibody (ab105350) at 1 µg/mL

All lanes:

293 cell lysate at 15 µg

Predicted band size: 60 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human KPNA6. The exact immunogen used to generate this antibody is proprietary information.

O60684

Specificity

ab105350 is predicted to not crossreact with other Importin alpha family members.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KPNA6 also known as importin alpha 7 functions in the nuclear import of proteins. It acts by forming a complex with importin beta allowing proteins to pass through the nuclear pore complex. KPNA6 has a molecular mass of approximately 60 kDa. Expression of KPNA6 occurs in several tissues including liver brain and testes emphasizing its widespread role in various physiological processes.
Biological function summary

KPNA6 facilitates the translocation of proteins containing a nuclear localization signal into the nucleus. It is part of the classical importin alpha/beta complex where it binds cargo proteins and importin beta recognizes the nuclear pore complex. This interaction is essential for the regulation of gene expression DNA replication and cell cycle progression. KPNA6 participates in coordinating these cellular processes by ensuring proteins enter the nucleus with timely precision.

Pathways

Nuclear transport mechanisms involve KPNA6 prominently. It plays a significant role in the nucleocytoplasmic transport pathway also contributing to the regulation of the cell cycle. Proteins related to these pathways include importin beta which partners with KPNA6 for efficient nuclear protein import. These pathways maintain cellular homeostasis and enable response to cellular stress or changes.

KPNA6 links to cancer progression and certain viral infections. Its dysregulation can affect tumor suppressor proteins and oncogenes leading to abnormal cell growth and cancer. KPNA6's interaction with viral proteins like those from HIV highlights its importance in viral pathogenesis where the virus exploits the nuclear import mechanism for replication. Understanding KPNA6 interactions provides insights into therapeutic targets for these conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
See full target information KPNA6
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death and differentiation 22:1775-84 PubMed25822340

2015

Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry.

Applications

Unspecified application

Species

Unspecified reactive species

S Marathe,S Liu,E Brai,M Kaczarowski,L Alberi
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB68153

Anti-STAT3 antibody [EPR787Y]

KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Western blot - Anti-STAT3 antibody [EPR787Y] (AB68153)

  • 4
  • 10
Primary Antibodies

AB131281

Anti-Exportin-5 antibody [EPR8453]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Exportin-5 antibody [EPR8453] (AB131281)

  • 4
  • 1
Primary Antibodies

AB318133

Anti-XRN2 antibody [EPR28598-13] - BSA and Azide free

BOND RX™ Validated|Recombinant|RabMAb

Immunocytochemistry/ Immunofluorescence - Anti-XRN2 antibody [EPR28598-13] - BSA and Azide free (AB318133)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com