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Rabbit Polyclonal KRT71 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human KRT71 aa 400 to C-terminus.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT71 antibody (AB247090), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human KRT71 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q3SY84

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested

Tested
Tested

Species
Human
Dilution info
1/1000.00000 - 1/2500.00000
Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target data

Function

Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.

Alternative names

K6IRS1, KB34, KRT6IRS1, KRT71, Cytokeratin-71, Keratin-71, Type II inner root sheath-specific keratin-K6irs1, Type-II keratin Kb34, CK-71, K71, Keratin 6 irs, hK6irs, hK6irs1

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Rabbit Polyclonal KRT71 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human KRT71 aa 400 to C-terminus.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Recombinant Fragment Protein within Human KRT71 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q3SY84
Purification technique
Affinity purification Immunogen
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

KRT71 or Keratin 71 is a type II keratin protein that plays an important role in hair and skin structure. It weighs about 57 kDa and primarily expresses in hair follicles where it partners with other keratin proteins to form the intermediate filaments. These filaments provide mechanical strength and resilience to the cells in the hair shaft and contribute to the proper formation of hair structure.

Biological function summary

Keratin 71 functions in tandem with other keratins like KRT75 and KRT6. It forms heterodimer complexes important for hair filament assembly affecting texture and rigidity. This protein also participates in the wider architecture of the epidermis supporting skin barrier function. KRT71's proper expression and function ensure effective protection against physical and microbial insults.

Pathways

KRT71 integrates into structural pathways related to keratinization and cornification. In these pathways it partners with proteins such as KRT6A and KRT83 influencing cell adhesion and differentiation. These pathways maintain skin integrity and are essential for the self-renewal and repair processes of the epidermis and hair follicles.

Associated diseases and disorders

Mutations or dysregulation in KRT71 expression have links to conditions like woolly hair syndrome and some hair shaft abnormalities. Research shows a connection with other keratins like KRT75 which can also affect hair texture and integrity. This highlights the necessity to understand KRT71's interactions in hair follicle biology for potential therapeutic approaches in dermatological disorders.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT71 antibody (ab247090), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT71 antibody (ab247090)

    Paraffin-embedded human hair tissue stained for KRT71 using ab247090 at 1/1000 dilution in immunohistochemical analysis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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