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AB247090

Anti-KRT71 antibody

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(1 Publication)

Rabbit Polyclonal KRT71 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KRT71 aa 400 to C-terminus.

View Alternative Names

K6IRS1, KB34, KRT6IRS1, KRT71, Cytokeratin-71, Keratin-71, Type II inner root sheath-specific keratin-K6irs1, Type-II keratin Kb34, CK-71, K71, Keratin 6 irs, hK6irs, hK6irs1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT71 antibody (AB247090)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT71 antibody (AB247090)

Paraffin-embedded human hair tissue stained for KRT71 using ab247090 at 1/1000 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human KRT71 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q3SY84

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KRT71 or Keratin 71 is a type II keratin protein that plays an important role in hair and skin structure. It weighs about 57 kDa and primarily expresses in hair follicles where it partners with other keratin proteins to form the intermediate filaments. These filaments provide mechanical strength and resilience to the cells in the hair shaft and contribute to the proper formation of hair structure.
Biological function summary

Keratin 71 functions in tandem with other keratins like KRT75 and KRT6. It forms heterodimer complexes important for hair filament assembly affecting texture and rigidity. This protein also participates in the wider architecture of the epidermis supporting skin barrier function. KRT71's proper expression and function ensure effective protection against physical and microbial insults.

Pathways

KRT71 integrates into structural pathways related to keratinization and cornification. In these pathways it partners with proteins such as KRT6A and KRT83 influencing cell adhesion and differentiation. These pathways maintain skin integrity and are essential for the self-renewal and repair processes of the epidermis and hair follicles.

Mutations or dysregulation in KRT71 expression have links to conditions like woolly hair syndrome and some hair shaft abnormalities. Research shows a connection with other keratins like KRT75 which can also affect hair texture and integrity. This highlights the necessity to understand KRT71's interactions in hair follicle biology for potential therapeutic approaches in dermatological disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.
See full target information KRT71
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 43:4298-4323 PubMed39160272

2024

CHC22 clathrin recruitment to the early secretory pathway requires two-site interaction with SNX5 and p115.

Applications

Unspecified application

Species

Unspecified reactive species

Joshua Greig,George T Bates,Daowen I Yin,Kit Briant,Boris Simonetti,Peter J Cullen,Frances M Brodsky
View all publications
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Product promise

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