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AB127030

Anti-KRT72 antibody

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(2 Publications)

Rabbit Polyclonal KRT72 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KRT72 aa 200-450.

View Alternative Names

K6IRS2, KB35, KRT6, KRT6IRS2, KRT72, Cytokeratin-72, Keratin-72, Type II inner root sheath-specific keratin-K6irs2, Type-II keratin Kb35, CK-72, K72

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT72 antibody (AB127030)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT72 antibody (AB127030)

ab127030, at 1/500 dilution, staining KRT72 in paraffin-embedded Human colon carcinoma tissue by Immunohistochemistry.

Western blot - Anti-KRT72 antibody (AB127030)
  • WB

Unknown

Western blot - Anti-KRT72 antibody (AB127030)

10% SDS-PAGE

All lanes:

Western blot - Anti-KRT72 antibody (ab127030) at 1/1000 dilution

All lanes:

NT2D1 whole cell lysate at 30 µg

Predicted band size: 56 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human KRT72 aa 200-450. The exact immunogen used to generate this antibody is proprietary information.

Q14CN4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Product details

Store undiluted.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KRT72 also known as Keratin 72 is a type II keratin protein with a molecular mass of approximately 55 kDa. This protein is an essential structural component of the intermediate filament family contributing to the structural integrity of cells. KRT72 mainly expresses in the hair follicle especially in the inner root sheath of hair fibers. In these regions it plays a significant role in maintaining the organization and mechanical properties necessary for hair development and health.
Biological function summary

The function of Keratin 72 extends beyond structural support. It contributes to the differentiation and proliferation of keratinocytes cells important for forming the epidermal layer of the skin. KRT72 effectively integrates into the keratin filament complex working alongside other type I and type II keratins. This integration is critical for establishing the strong filamentous networks that resist mechanical stress within epithelial cells ensuring proper tissue formation and maintenance.

Pathways

Keratin 72 operates within the hair follicle regulation pathway a process vital for hair cycling and regeneration. This protein's activity also intersects with the epithelial cell differentiation pathway where it works with proteins like Keratin 6 and Keratin 16. These interactions help regulate the normal cycling of hair growth phases and maintain epithelial tissue integrity highlighting KRT72's importance in cellular processes related to skin and hair.

Defects or alterations in KRT72 expression have potential links to hair abnormalities such as hypotrichosis a condition characterized by reduced hair growth. Additionally disruptions in Keratin 72 can impact the integrity of epithelial tissues possibly contributing to skin conditions such as epidermolysis bullosa. In this context its interaction with other keratins like Keratin 74 may modulate disease development highlighting the importance of Keratin 72 in preserving normal cellular and tissue functions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).
See full target information KRT72
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:2998 PubMed40148322

2025

Keratin-72 restricts HIV-1 infection in resting CD4 T cells by sequestering capsids in intermediate filaments.

Applications

Unspecified application

Species

Unspecified reactive species

Yang He,Meng Xu,Jiayue Ouyang,Li Zhao,Tiankui Ma,Xiaowei Zhang,Ruolin Wang,Hong Shang,Guoxin Liang

American journal of physiology. Heart and circulat 307:H976-86 PubMed25108012

2014

Role of blood and vascular smooth muscle in the vasoactivity of nitrite.

Applications

Unspecified application

Species

Unspecified reactive species

Taiming Liu,Hobe J Schroeder,Lisa Barcelo,Shannon L Bragg,Michael H Terry,Sean M Wilson,Gordon G Power,Arlin B Blood
View all publications
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