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AB254953

Anti-KRT79 antibody

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(1 Publication)

Rabbit Polyclonal KRT79 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KRT79 aa 1-100.

View Alternative Names

K6L, KB38, KRT6L, KRT79, Cytokeratin-79, Keratin-6-like, Keratin-79, Type-II keratin Kb38, CK-79, Keratin-6L, K79

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT79 antibody (AB254953)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT79 antibody (AB254953)

Paraffin-embedded human tonsil tissue stained for KRT79 using ab254953 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT79 antibody (AB254953)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT79 antibody (AB254953)

Paraffin-embedded human skeletal muscle tissue stained for KRT79 using ab254953 at 1/500 dilution in immunohistochemical analysis. Low expression as expected.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT79 antibody (AB254953)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT79 antibody (AB254953)

Paraffin-embedded human skin tissue stained for KRT79 using ab254953 at 1/500 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human KRT79 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q5XKE5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KRT79 also known as Keratin 79 is a type II cytokeratin with a molecular mass of approximately 53 kDa. This keratin is mainly expressed in the epithelial cells particularly in the epidermis and hair follicles. It plays an important role in the structural integrity and mechanical maintenance of these tissues by forming intermediate filaments. As a component of the cytoskeleton KRT79 helps cells withstand mechanical stress and provides resilience to the outer layer of skin.
Biological function summary

Keratin 79 contributes to the formation and maintenance of the cellular cytoskeletal framework. It is not found as an isolated protein but rather as part of a complex filamentous network in keratinocytes where it interacts with other keratins like KRT5 and KRT14. This network not only confers mechanical support to the cells but also participates in cell signaling processes that regulate cell growth and differentiation within the epidermis. Essential for maintaining the homeostasis of the skin Keratin 79 ensures the proper functioning and renewal of epithelial tissues.

Pathways

The cellular roles of Keratin 79 are involved in the keratinization pathway and the epidermal development pathway. These biological pathways are important for skin barrier function and involve other keratins such as KRT6 and KRT16. Through these pathways KRT79 appears essential for promoting the resilience and flexibility of the epidermis during physical and environmental stress as well as maintaining protective features against external insults.

Defects or dysregulation in Keratin 79 expression can contribute to disorders like alopecia and epidermolysis bullosa simplex. These conditions often involve abnormal keratinization or compromised skin integrity. KRT79's interaction with proteins like filaggrin and involucrins may exacerbate these disorders when their expression or function becomes irregular. This connection highlights the significance of Keratin 79 in skin and hair follicle health suggesting potential targets for therapeutic intervention in related conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information KRT79
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging 12: PubMed33493134

2021

Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Pengfei Zhu,Ruo Feng,Xu Lu,Yuan Liao,Zhicheng Du,Wenlong Zhai,Kunlun Chen
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Product promise

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