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AB169303

Anti-KRT81 antibody

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(1 Publication)

Rabbit Polyclonal KRT81 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KRT81.

View Alternative Names

KRTHB1, MLN137, KRT81, Hair keratin K2.9, Keratin-81, Metastatic lymph node 137 gene protein, Type II hair keratin Hb1, Type-II keratin Kb21, ghHKb1, K81, MLN 137, ghHb1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human KRT81.

Q14533

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Alternative Products

Primary Antibodies

AB55407

Anti-KRT81 antibody [3B10-5B10]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRT81 antibody [3B10-5B10] (AB55407)

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Complementary Products

Primary Antibodies

AB93279

Anti-Cytokeratin 6 antibody [EPR1602Y]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 6 antibody [EPR1602Y] (AB93279)

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Primary Antibodies

AB92551

Anti-Cytokeratin 13 antibody [EPR3671]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 13 antibody [EPR3671] (AB92551)

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  • 2
Primary Antibodies

AB51599

Anti-Cytokeratin 4 antibody [EP1599Y]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 4 antibody [EP1599Y] (AB51599)

  • 5
  • 1
Primary Antibodies

AB16112

Anti-Cytokeratin 13 antibody [AE8]

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 13 antibody [AE8] (AB16112)

  • 5
  • 4
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KRT81 also known as Keratin 81 or Hair Keratin K2.9 is a type II keratin protein with a molecular mass of approximately 55 kDa. This protein is mechanical forming intermediate filaments that provide structural support in the cells. KRT81 is primarily found in hair follicles especially in the cortex of hair fibers where it plays a role in the formation and stabilization of hair structure. Its highly regulated expression is critical during hair development and growth.
Biological function summary

KRT81 contributes to the rigidity and integrity of hair by interacting within a keratin complex. This complex includes other keratin proteins that support the polymerization process needed for filament formation. The presence of KRT81 in non-dividing differentiating cells in the hair follicle indicates its important role during the hair cycle stages ensuring the mechanical strength needed for protective and sensory functions.

Pathways

Several biological processes depend on the structural role of KRT81. It is part of the keratinization pathway which is essential for hair formation impacting the assembly of hair alongside other keratin proteins such as KRT31 and KRT35. These proteins work together to create the strong keratin structure necessary for healthy hair development. KRT81 interacts within a network that influences hair shaft differentiation.

KRT81 mutations can lead to hair-related conditions. One such disorder is Monilethrix characterized by beaded hair and hair shaft abnormalities. In Monilethrix changes in KRT81 can disrupt the protein network impacting other keratins like KRT83 and leading to fragile hair. Understanding these connections helps in developing therapies aimed at treating hair-related disorders by targeting specific points in the keratin protein network.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information KRT81
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 44:1294-1321 PubMed39905228

2025

Multimodal mechanisms of human centriole engagement and disengagement.

Applications

Unspecified application

Species

Unspecified reactive species

Kei K Ito,Kasuga Takumi,Kyohei Matsuhashi,Hirokazu Sakamoto,Kaho Nagai,Masamitsu Fukuyama,Shohei Yamamoto,Takumi Chinen,Shoji Hata,Daiju Kitagawa
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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