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AB222253

Anti-KRTAP11-1 antibody

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(1 Publication)

Rabbit Polyclonal KRTAP11-1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KRTAP11-1 aa 50-150.

View Alternative Names

KAP11.1, KRTAP11.1, KRTAP11-1, Keratin-associated protein 11-1, High sulfur keratin-associated protein 11.1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRTAP11-1 antibody (AB222253)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KRTAP11-1 antibody (AB222253)

Paraffin embedded human hair stained for KRTAP11-1 with ab222253 at a 1/50 dilution in Immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human KRTAP11-1 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q8IUC1

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Alternative Products

Primary Antibodies

AB181231

Anti-KRTAP11-1 antibody [EPR13181]

RabMAb|Recombinant

Western blot - Anti-KRTAP11-1 antibody [EPR13181] (AB181231)

  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KRTAP11-1 also known as Keratin-Associated Protein 11-1 is a structural protein with a mass of about 12 kDa. It is part of the family of Keratin-Associated Proteins (KAPs) that play an important role in the architecture of hair fibers. This protein expresses mainly in hair follicles specifically in the cortex and cuticle regions. By binding to keratin proteins KRTAP11-1 contributes to forming the rigid hair structure.
Biological function summary

This protein interacts within the microenvironment of hair follicles to influence hair fiber integrity and rigidity. KRTAP11-1 does not operate within a larger protein complex but its interactions with various keratin types are essential for hair formation and mechanical resilience. Through these interactions it helps control the physicochemical properties of hair impacting characteristics like elasticity and resistance to damage.

Pathways

Research has shown that this protein links to the specialized pathway of hair keratinization which is part of the general epidermis development process. KRTAP11-1 works alongside keratin proteins many of which belong to the type I and type II keratins in this pathway. This interaction supports the orderly assembly and stabilization of the keratin filament network that gives hair its structural integrity.

Studies have associated mutations or irregular expressions of KRTAP11-1 with conditions such as hair disorders like trichothiodystrophy and fragile hair syndrome. These conditions often involve abnormalities in the keratinization process. The protein's relationship with keratin-related proteins may contribute to these disorders when mutations disrupt proper hair structure formation. Such disruptions highlight the importance of understanding KRTAP11-1's role in hair maintenance and formation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
See full target information KRTAP11-1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 9:647763 PubMed34055778

2021

EPC-Derived Exosomal miR-1246 and miR-1290 Regulate Phenotypic Changes of Fibroblasts to Endothelial Cells to Exert Protective Effects on Myocardial Infarction by Targeting ELF5 and SP1.

Applications

Unspecified application

Species

Unspecified reactive species

Yulang Huang,Lifang Chen,Zongming Feng,Weixin Chen,Shaodi Yan,Rongfeng Yang,Jian Xiao,Jiajia Gao,Debao Zhang,Xiao Ke
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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