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AB181231

Anti-KRTAP11-1 antibody [EPR13181]

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(1 Publication)

Rabbit Recombinant Monoclonal KRTAP11-1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

KAP11.1, KRTAP11.1, KRTAP11-1, Keratin-associated protein 11-1, High sulfur keratin-associated protein 11.1

1 Images
Western blot - Anti-KRTAP11-1 antibody [EPR13181] (AB181231)
  • WB

Supplier Data

Western blot - Anti-KRTAP11-1 antibody [EPR13181] (AB181231)

All lanes:

Western blot - Anti-KRTAP11-1 antibody [EPR13181] (ab181231) at 1/5000 dilution

All lanes:

Human skin lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab136636'>ab136636</a>) at 1/1000 dilution

Predicted band size: 17 kDa

false

  • Carrier free

    Anti-KRTAP11-1 antibody [EPR13181] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR13181

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Conditional Ambient
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KRTAP11-1 also known as Keratin-Associated Protein 11-1 is a structural protein with a mass of about 12 kDa. It is part of the family of Keratin-Associated Proteins (KAPs) that play an important role in the architecture of hair fibers. This protein expresses mainly in hair follicles specifically in the cortex and cuticle regions. By binding to keratin proteins KRTAP11-1 contributes to forming the rigid hair structure.
Biological function summary

This protein interacts within the microenvironment of hair follicles to influence hair fiber integrity and rigidity. KRTAP11-1 does not operate within a larger protein complex but its interactions with various keratin types are essential for hair formation and mechanical resilience. Through these interactions it helps control the physicochemical properties of hair impacting characteristics like elasticity and resistance to damage.

Pathways

Research has shown that this protein links to the specialized pathway of hair keratinization which is part of the general epidermis development process. KRTAP11-1 works alongside keratin proteins many of which belong to the type I and type II keratins in this pathway. This interaction supports the orderly assembly and stabilization of the keratin filament network that gives hair its structural integrity.

Studies have associated mutations or irregular expressions of KRTAP11-1 with conditions such as hair disorders like trichothiodystrophy and fragile hair syndrome. These conditions often involve abnormalities in the keratinization process. The protein's relationship with keratin-related proteins may contribute to these disorders when mutations disrupt proper hair structure formation. Such disruptions highlight the importance of understanding KRTAP11-1's role in hair maintenance and formation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
See full target information KRTAP11-1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 290:14729-39 PubMed25911105

2015

Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon.

Applications

Unspecified application

Species

Unspecified reactive species

Qinjie Zhou,Alfonso Lavorgna,Melissa Bowman,John Hiscott,Edward W Harhaj
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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