Anti-KRTHA3B antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

KRTHA3B also known as keratin 83 is a type II hair keratin protein with a molecular mass of approximately 50 kDa. This protein functions mechanically as a structural component in the assembly of intermediate filaments in hair and nail tissues. KRTHA3B forms a critical part of the cytoskeleton in these cells conferring resilience and structural integrity. It expresses prominently in hair follicles and nail beds which is essential for maintaining the strength and rigidity of keratinized tissues.

Biological function summary

Keratins like KRTHA3B are key in building the fibrous framework necessary for tissue stability and function in epithelial cells. KRTHA3B associates with other keratin proteins forming complex networks that are involved in the mechanical support of epithelial cells. Such networks maintain the shape and mechanical resistance required by the cells particularly in the rapidly growing and dividing cells in hair follicles. This protein contributes to filament stabilization ensuring that the structure remains tight and resistant to physical stress.

Pathways

Keratin proteins including KRTHA3B play essential roles in epithelial cell differentiation and structural maintenance. They integrate into pathways such as epithelial-mesenchymal transition (EMT) and cell adhesion playing roles in cellular adhesion dynamics. Related proteins include keratin 19 and keratin 14 which participate together to maintain epithelial cell integrity and function. These pathways ensure structural stability and reliable barrier functions in tissues.

Associated diseases and disorders

The mutation or deregulation of KRTHA3B can associate with conditions such as hair disorders and some nail dystrophies. Keratin-related disorders often result from dysfunctional filament assembly or structure affecting the affected tissues' resilience. Connected proteins in these disorders include keratin 5 and keratin 17 which are involved in similar filament assembly processes and can contribute to appearance and functionality defects when mutated or expressed incorrectly.