Anti-KSHV ORF45 antibody [2D4A5]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

KSHV ORF45 also known as Kaposi’s sarcoma-associated herpesvirus ORF45 functions as an immediate-early protein. Researchers have identified its molecular weight around 48 kDa. It expresses in the cytoplasm of infected cells during the lytic cycle of KSHV a human herpesvirus. This protein inhibits the antiviral response by interacting with host cell signaling pathways making it an important component of the virus's lifecycle.

Biological function summary

The function of KSHV ORF45 impacts cellular processes that are essential for viral replication and immune evasion. This protein interacts with several signaling molecules such as RSK and ERK which are part of the host cell's defense mechanisms. It prevents cellular apoptosis and supports viral gene expression by inhibiting the host's innate immune response. KSHV ORF45 does not exist as part of a larger protein complex but operates through direct protein-protein interactions.

Pathways

Research shows that KSHV ORF45 modifies the MAPK/ERK signaling pathway. This pathway is critical for cell proliferation and survival aiding the virus in evading host immunity and establishing infection. The protein closely links with RSK1/2 important in transducing ERK signals. This modification affects the host cell's ability to mount an effective antiviral response supporting viral pathogenesis.

Associated diseases and disorders

Delineating the role of KSHV ORF45 connects it to Kaposi's sarcoma and primary effusion lymphoma. These malignancies occur frequently in individuals with compromised immune systems like those with AIDS. KSHV ORF45 indirectly links with proteins such as LANA and vIL-6 which contribute to cellular transformation and oncogenesis. Understanding this protein’s role offers insights into potential therapeutic targets for KSHV-related malignancies.