Anti-kur antibody [EPR13320-66] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Kur also known as the voltage-gated potassium channel subunit Kv3.x is an integral membrane protein involved in potassium ion transport across cell membranes. With a molecular mass of approximately 85 kDa this channel exhibits a high expression level in central nervous system tissues particularly in neurons. It plays a critical role in modulating neuronal excitability and signal transmission by facilitating rapid repolarization of the action potential.

Biological function summary

The voltage-gated potassium channel Kv3.x influences neurotransmitter release and neuronal firing rate. This target does not function alone; rather it forms a part of a larger channel complex. Through these channels Kv3.x regulates the rapid spike frequency adaptation enabling neurons to maintain high-frequency firing without depolarization block. By contributing to electrical signaling precision it supports diverse neuronal circuit activities.

Pathways

The potassium channel Kv3.x integrates into the neuronal excitability pathway affecting both synaptic transmission and plasticity. It interacts with key proteins like Nav1.6 a voltage-gated sodium channel as they complement each other's roles in action potential propagation. Kv3.x also participates in the broader potassium ion homeostasis pathway which involves other ion channels and transporters to maintain neuronal ion balance and function.

Associated diseases and disorders

Dysregulation of Kv3.x channels associates with neurological conditions such as epilepsy and schizophrenia. Altered expression or function of Kv3.x can lead to increased neuronal excitability contributing to seizure susceptibility in epilepsy. In schizophrenia abnormal Kv3.x activity could disrupt normal auditory processing potentially through interactions with proteins like NMDA receptors. These associations highlight the importance of Kv3.x in maintaining neural health and signaling fidelity.