Rabbit Polyclonal Kv1.4/RK3 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 2 publications.
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Publications
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- JCI insight 3:2018Reverse electrical remodeling in rats with heart failure and preserved ejection fraction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJae Hyung Cho et. al.PubMed 30282820
- Journal of acupuncture and meridian studies 11:88-962018The Beneficial Effects of Electroacupuncture at PC6 Acupoints (Neiguan) on Myocardial Ischemia in ASIC3 -/- mice.Applications:WBReactive species:Unspecified reactive speciesYing-Wang,Wan-Shuang Zhao,Di Li,Ya-Han Xu,Meng-di Li,Jin Chen,Zhi-Jun Kou,Qi-Ge Wang,Yi-Guo Chen,Nsoa Dimitri JosephPubMed 29608997
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.08% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Tested |
| Cow | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1.00000-10.00000 µg/mL | Notes Detects a band of approximately 76 KDa in HEK293 lysate and 90 kDa in rat hippocampal membranes. |
Species Human | Dilution info 1.00000-10.00000 µg/mL | Notes Detects a band of approximately 76 KDa in HEK293 lysate and 90 kDa in rat hippocampal membranes. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Cow | Dilution info - | Notes - |
Associated Products
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Target data
Function
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368).
Alternative names
KCNA4L, KCNA4, Potassium voltage-gated channel subfamily A member 4, HPCN2, Voltage-gated K(+) channel HuKII, Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, Voltage-gated potassium channel subunit Kv1.4
Recommended products
Rabbit Polyclonal Kv1.4/RK3 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 2 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.08% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
- Precipitation Ammonium Sulphate
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Kv1.4 also known as RK3 functions as a voltage-gated potassium channel. It allows for potassium ions to move across the cell membrane in response to changes in membrane potential. This channel has a molecular mass around 75 kDa. Kv1.4 is mainly expressed in cardiac and neuronal tissues where it plays an important role in action potential repolarization. Its expression ensures proper electrical signaling in these tissues.
- Biological function summary
The Kv1.4 channel contributes to the regulation of action potentials in both the heart and nervous system. It is part of a larger complex of potassium channels that work together to fine-tune neuronal excitability and muscle contraction. The function of Kv1.4 is essential for maintaining the balance of excitation and inhibition in cells impacting how electrical signals are transmitted.
- Pathways
Kv1.4 has a significant role in the cardiac action potential pathway and the neural signaling pathway. In the cardiac pathway it interacts with other potassium channels like Kv1.2 and Kv1.1 to ensure the timely repolarization of the cardiac action potential. In neural tissues Kv1.4 affects neurotransmitter release and neuronal firing rates interacting with proteins such as synaptotagmin in the synaptic vesicle fusion process.
- Associated diseases and disorders
Kv1.4 mutations and dysregulation are connected to cardiac arrhythmias and epilepsy. Altered Kv1.4 function can disrupt the cardiac rhythm leading to arrhythmogenic conditions. In epilepsy abnormal Kv1.4 activity may lead to imbalanced neuronal excitability which can contribute to seizure disorders. Kv1.4 interacts with other proteins like Nav1.1 in these disease states to exacerbate or mitigate symptoms.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-Kv1.4/RK3 antibody (ab16718)
Western blots using ab16718.
1: HEK293 cells transfected with Kv1.4/RK3.
2: Rat hippocampal membrane.
The size difference observed can probably be explained by differential post-translational processing.All lanes: Western blot - Anti-Kv1.4/RK3 antibody (ab16718)
Predicted band size: 73 kDa
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