AB167274

Anti-kynurenine 3-monooxygenase antibody

Name: Anti-kynurenine 3-monooxygenase antibody (ab167274) | Abcam
Brand: Abcam Limited
SKU: AB167274

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(3 Publications)

Mouse Polyclonal kynurenine 3-monooxygenase antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human kynurenine 3-monooxygenase.

View Alternative Names

Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase, KMO

1 Images

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Western blot - Anti-kynurenine 3-monooxygenase antibody (AB167274)

All lanes:

Western blot - Anti-kynurenine 3-monooxygenase antibody (ab167274) at 1 µg/mL

Lane 1:

Kynurenine 3-monooxygenase transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected lysate at 15 µL

Predicted band size: 56 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human kynurenine 3-monooxygenase.

O15229

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kynurenine 3-monooxygenase (KMO) also known as kynurenine 3-hydroxylase is an enzyme that plays a mechanical role in the kynurenine pathway. This enzyme catalyzes the conversion of L-kynurenine to 3-hydroxykynurenine. KMO has a molecular mass of approximately 55 kDa. It is primarily expressed in the liver and kidney tissues but can also be found in other organs at lower levels. The structure of KMO contains a flavin adenine dinucleotide (FAD) binding domain which is essential for its oxidoreductase activity.

Biological function summary

KMO participates in the degradation of tryptophan significantly impacting the biosynthesis of nicotinamide adenine dinucleotide (NAD+). KMO is not known to be part of any protein complexes but its enzymatic activity is important for the production of downstream metabolites that influence various physiological processes. This activity affects immune response neurogenesis and energy metabolism highlighting its role in maintaining metabolic balance.

Pathways

KMO is an integral component of the kynurenine pathway which is critical for tryptophan catabolism. It associates closely with other enzymes like kynureninase and kynurenine aminotransferase. KMO exerts its function by regulating the levels of neuroactive and immunoactive metabolites in the brain and peripheral tissues. Through its role in the kynurenine pathway KMO influences cellular signaling and energy production connecting to broader metabolic pathways.

KMO plays a significant role in neurodegenerative diseases such as Alzheimer's and Huntington's disease. Altered KMO activity leads to an imbalance of kynurenine pathway metabolites impacting neuronal health. The enzyme's dysfunction also associates with psychiatric disorders like schizophrenia. The relationship between KMO and other kynurenine pathway enzymes like kynurenine aminotransferase suggests that modulating its activity could present therapeutic opportunities for these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed : 23575632, PubMed : 26752518, PubMed : 28604669, PubMed : 29208702, PubMed : 29429898). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).

See full target information kynurenine 3-monooxygenase

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Actas espanolas de psiquiatria 52:693-704 PubMed39403905

2024

Mechanism of Treadmill Exercise Combined with Rich Environmental Stimulation to Improve Depression in Post-stroke Depression Model Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Lina Lu,Wenting Xu,Lin Feng,Xiuying Teng,Weigu Ban,Yuman Xue,Xueliang Xing,Wen Zeng,Baolong Li

The Journal of clinical endocrinology and metabolism 110:693-705 PubMed39183149

2024

BRAF-induced EHF Expression Affects TERT in Aggressive Papillary Thyroid Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yiyi Xu,Jiwei Gao,Na Wang,Jan Zedenius,Inga-Lena Nilsson,Weng-Onn Lui,Dawei Xu,C Christofer Juhlin,Catharina Larsson,Ninni Mu

Journal of gastrointestinal oncology 14:516-532 PubMed37201083

2023

in the promotion of tumor development and progression in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Xu,Jianping Song,Xinmin Zeng,Yanqin Hu,Jingru Kuang

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Product promise

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Anti-kynurenine 3-monooxygenase antibody

Western blot - Anti-kynurenine 3-monooxygenase antibody (AB167274)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise