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AB167315

Anti-l-Myc antibody

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(1 Publication)

Mouse Polyclonal L-Myc/MYCL antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MYCL.

View Alternative Names

BHLHE38, LMYC, MYCL1, MYCL, Protein L-Myc, Class E basic helix-loop-helix protein 38, Protein L-Myc-1, V-myc myelocytomatosis viral oncogene homolog, bHLHe38

1 Images
Western blot - Anti-l-Myc antibody (AB167315)
  • WB

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Western blot - Anti-l-Myc antibody (AB167315)

All lanes:

Western blot - Anti-l-Myc antibody (ab167315) at 1 µg/mL

Lane 1:

l-Myc-transfected 293T cell line lysate at 15 µL

Lane 2:

Non-transfected lysate at 15 µL

Predicted band size: 36 kDa,40 kDa,43 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MYCL.

P12524

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Myc antibody [Y69] - ChIP Grade (AB32072)

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Primary Antibodies

AB199489

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Primary Antibodies

AB240640

Anti-CHD4 antibody [EPR22953-38] - ChIP Grade

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Flow Cytometry (Intracellular) - Anti-CHD4 antibody [EPR22953-38] - ChIP Grade (AB240640)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The l-Myc protein also known as L-Myc1 or LMyc is a member of the Myc family of transcription factors. It has a molecular weight around 39 kDa. Researchers find this protein expressed in various tissues but most often in neural and small cell lung cancer (SCLC) cells. As part of its mechanical function l-Myc binds to DNA at specific sequences regulating transcription of target genes involved in cell proliferation and differentiation.
Biological function summary

L-Myc plays a role in modulating cellular processes by forming dimer complexes with other proteins such as Max. In these complexes l-Myc influences the expression of genes linked to cell cycle control metabolism and growth signals. This regulation is essential in maintaining cellular balance and function under normal physiological conditions.

Pathways

L-Myc actively participates in the Myc-Max-Mad network which integrates signals for growth and proliferation. This network associates with important pathways like the MAPK/ERK pathway and the Wnt/β-catenin pathway. In these pathways l-Myc influences cellular responses alongside other Myc proteins like c-Myc and N-Myc which frequently collaborate or have overlapping functions.

L-Myc connects strongly with small cell lung cancer (SCLC) and neuroblastoma. In these cases amplification or overexpression of l-Myc is common often resulting in aggressive tumor growth. The interplay between l-Myc and other Myc family members such as c-Myc highlights their collective role in oncogenic processes driving unchecked cellular proliferation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information MYCL
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Anti-cancer drugs 27:756-65 PubMed27276402

2016

Antimyeloma activity of bromodomain inhibitors on the human myeloma cell line U266 by downregulation of MYCL.

Applications

WB

Species

Human

Kazuhito Suzuki,Kouhei Yamamoto,Yasuhiro Arakawa,Hisashi Yamada,Keisuke Aiba,Masanobu Kitagawa
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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