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AB80832

Anti-L1CAM antibody [UJ127] - BSA and Azide free

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(9 Publications )

Anti-L1CAM antibody [UJ127] - BSA and Azide free (ab80832) is a mouse monoclonal antibody provided in a PBS only buffer for easy conjugation detecting L1CAM in Flow Cytometry, IHC-P, ICC/IF. Suitable for Human.

- BSA, sodium azide, and glycerol-free for easy conjugation
- Trusted since 2009

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

UJ127

Isotype

IgG1

Light chain type

kappa

Carrier free

Yes

Reacts with

Human

Applications

IHC-FoFr, ICC/IF, IHC-P, Flow Cyt

applications

Immunogen

Tissue preparation containing L1CAM protein. The exact immunogen used to generate this antibody is proprietary information.

P32004

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCFoFr" : {"fullname" : "Immunohistochemistry (PFA perfusion fixed frozen sections)", "shortname":"IHC-FoFr"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "IHCFoFr-species-checked": "guaranteed", "IHCFoFr-species-dilution-info": "", "IHCFoFr-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Product details

What is this antibody validated in?
Anti-L1CAM antibody [UJ127] - BSA and Azide free (ab80832) is a mouse monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
pH: 7.2 - 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

L1CAM also known as neural cell adhesion molecule L1 is a transmembrane protein with a molecular weight of approximately 200-220 kDa. The L1CAM protein belongs to the immunoglobulin superfamily and is heavily glycosylated. It plays a significant role in cell adhesion processes within the nervous system. L1CAM is expressed in a variety of tissues including the brain kidney and peripheral nerves and is notably present in neuronal cells where it engages in cell-cell interactions. Researchers frequently use L1CAM IHC ELISA methods and specific fluorescent markers like Alexa Fluor 568 to study its expression patterns and localization.
Biological function summary

L1CAM facilitates neuronal migration axonal growth and synaptic plasticity. This protein participates in the formation and maintenance of neural networks. It interacts with other cell adhesion molecules and components of the extracellular matrix. L1CAM acts as an important modulator within neuronal signaling complexes which impacts the development and regeneration of the nervous system. Insights into its structural and cell interaction properties have made it a focus for understanding nervous system functions.

Pathways

L1CAM participates extensively in the MAPK and PI3K/AKT pathways. These pathways contribute to cellular growth survival and programmed cell death. The protein interacts with other molecules such as integrins and FGFRs to propagate signaling cascades important for cellular response mechanisms. These connections help modulate cytoskeletal dynamics influencing cellular adhesion and motility needed during brain development and response to injury.

L1CAM has been associated with hydrocephalus and some cancers. Mutations in the L1CAM gene can lead to L1 syndrome which includes a spectrum of neurological disorders particularly hydrocephalus. In cancer overexpression or altered regulation of L1CAM may correlate with tumor aggressiveness and metastatic potential. L1CAM's association with integrin and cadherin proteins underlines its relevance in pathological states and highlights a potential target for therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
See full target information L1CAM

Alternative Names

CD171, CAML1, MIC5, L1CAM, Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1
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Publications (9)

Recent publications for all applications. Explore the full listand refine your search

Proceedings of the National Academy of Sciences of the United States of America 121:e2408949121 PubMed39475636

2024

Measurement of α-synuclein as protein cargo in plasma extracellular vesicles.

Applications

Unspecified application

Species

Human

Tal Gilboa,Dmitry Ter-Ovanesyan,Shih-Chin Wang,Sara Whiteman,George T Kannarkat,George M Church,Alice S Chen-Plotkin,David R Walt

Annals of neurology 92:230-245 PubMed35596947

2022

Parkinson's Disease Derived Exosomes Aggravate Neuropathology in SNCA*A53T Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Huang,Zongran Liu,Na Li,Chen Tian,Han Yang,Yanfei Huo,Yang Li,Jing Zhang,Zhenwei Yu

Movement disorders : official journal of the Movement Disorder Society 36:2663-2669 PubMed33826157

2021

Validation of α-Synuclein in L1CAM-Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Jiang,Franziska Hopfner,Daniela Berg,Michele T Hu,Andrea Pilotto,Barbara Borroni,Jason J Davis,George K Tofaris

Journal of neurology, neurosurgery, and psychiatry 91:720-729 PubMed32273329

2020

Serum neuronal exosomes predict and differentiate Parkinson's disease from atypical parkinsonism.

Applications

Unspecified application

Species

Unspecified reactive species

Cheng Jiang,Franziska Hopfner,Antigoni Katsikoudi,Robert Hein,Candan Catli,Samuel Evetts,Yongzhi Huang,Hong Wang,John W Ryder,Gregor Kuhlenbaeumer,Guenther Deuschl,Alessandro Padovani,Daniela Berg,Barbara Borroni,Michele T Hu,Jason J Davis,George K Tofaris

Acta neuropathologica 128:639-650 PubMed24997849

2014

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Min Shi,Changqin Liu,Travis J Cook,Kristin M Bullock,Yanchun Zhao,Carmen Ginghina,Yanfei Li,Patrick Aro,Romel Dator,Chunmei He,Michael J Hipp,Cyrus P Zabetian,Elaine R Peskind,Shu-Ching Hu,Joseph F Quinn,Douglas R Galasko,William A Banks,Jing Zhang

Journal of neurotrauma 31:553-64 PubMed24125017

2013

Analysis of human embryonic stem cells with regulatable expression of the cell adhesion molecule l1 in regeneration after spinal cord injury.

Applications

WB, IHC-FoFr

Species

Human, Human

Myungsik Yoo,Gunho Anthony Lee,Christopher Park,Rick I Cohen,Melitta Schachner

Experimental & molecular medicine 44:293-302 PubMed22248567

2012

A chimeric antibody to L1 cell adhesion molecule shows therapeutic effect in an intrahepatic cholangiocarcinoma model.

Applications

Unspecified application

Species

Unspecified reactive species

Eung Suk Lee,Mun Sik Jeong,Rohit Singh,Juyeon Jung,Hyunho Yoon,Jeong Ki Min,Kyung Hyun Kim,Hyo Jeong Hong

Biochemical Society transactions 18:274 PubMed2379713

1990

Monoclonal antibody UJ127.11 recognizes the human homologue of mouse L1 cell adhesion molecule.

Applications

Unspecified application

Species

Human

K Patel,F Kiely,F Rathjen,J Kemshead

International journal of cancer 31:187-95 PubMed6826247

1983

Monoclonal antibody UJ 127:11 detects a 220,000-240,000 kdal. glycoprotein present on a sub-set of neuroectodermally derived cells.

Applications

IHC-P, ICC/IF

Species

Human, Human

J T Kemshead,J Fritschy,J A Garson,P Allan,H Coakham,S Brown,U Asser
View all publications
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Product promise

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