Anti-LAF4 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

LAF4 also known as lymphoid nuclear protein related to AF4 is a transcription factor involved in gene regulation. It weighs approximately 110 kDa and acts primarily in the nucleus. LAF4 shows expression mainly in lymphoid tissues such as the spleen and thymus. It contains an amino acid sequence that facilitates interactions with other proteins allowing it to function effectively in transcriptional modulation.

Biological function summary

LAF4 influences the regulation of specific genes critical for immune function. It often participates in multiprotein complexes interacting with other cofactors that modify chromatin structure. LAF4's role in regulating transcription contributes to the control of cell differentiation and proliferation within the immune system. Additionally LAF4 is important for maintaining the balance between progenitor cell self-renewal and differentiation.

Pathways

LAF4 integrates into the Wnt signaling pathway which affects cell fate decisions migration and organogenesis. It interacts with proteins like beta-catenin and regulates downstream gene expression. LAF4 also plays a role in the Notch signaling pathway which has broad effects on development and immune responses. Cross-talk between LAF4 and other proteins in these pathways enables coordinated regulation of differentiation and development processes.

Associated diseases and disorders

LAF4 correlates with certain cancers such as leukemia. Its dysregulation can lead to abnormal cell proliferation and survival often resulting from gene translocation events. LAF4 interacts with proteins like AF4 and is involved in leukemic transformations. Furthermore aberrant expression of LAF4 may link to autoimmune conditions given its regulatory role in the immune response and lymphoid tissue development.