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AB106231

Anti-LAF4 antibody

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(1 Publication)

Rabbit Polyclonal LAF4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human AFF3.

View Alternative Names

LAF4, AFF3, AF4/FMR2 family member 3, Lymphoid nuclear protein related to AF4, Protein LAF-4

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LAF4 antibody (AB106231)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LAF4 antibody (AB106231)

ab106231 at 1/100 dilution staining LAF4 in Human fetal lymphoid by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Western blot - Anti-LAF4 antibody (AB106231)
  • WB

Unknown

Western blot - Anti-LAF4 antibody (AB106231)

All lanes:

Western blot - Anti-LAF4 antibody (ab106231) at 1/500 dilution

Lane 1:

Raji cell lysate

Lane 2:

BJAB cell lysate

Predicted band size: 133 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human AFF3. The exact immunogen used to generate this antibody is proprietary information.

P51826

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LAF4 also known as lymphoid nuclear protein related to AF4 is a transcription factor involved in gene regulation. It weighs approximately 110 kDa and acts primarily in the nucleus. LAF4 shows expression mainly in lymphoid tissues such as the spleen and thymus. It contains an amino acid sequence that facilitates interactions with other proteins allowing it to function effectively in transcriptional modulation.
Biological function summary

LAF4 influences the regulation of specific genes critical for immune function. It often participates in multiprotein complexes interacting with other cofactors that modify chromatin structure. LAF4's role in regulating transcription contributes to the control of cell differentiation and proliferation within the immune system. Additionally LAF4 is important for maintaining the balance between progenitor cell self-renewal and differentiation.

Pathways

LAF4 integrates into the Wnt signaling pathway which affects cell fate decisions migration and organogenesis. It interacts with proteins like beta-catenin and regulates downstream gene expression. LAF4 also plays a role in the Notch signaling pathway which has broad effects on development and immune responses. Cross-talk between LAF4 and other proteins in these pathways enables coordinated regulation of differentiation and development processes.

LAF4 correlates with certain cancers such as leukemia. Its dysregulation can lead to abnormal cell proliferation and survival often resulting from gene translocation events. LAF4 interacts with proteins like AF4 and is involved in leukemic transformations. Furthermore aberrant expression of LAF4 may link to autoimmune conditions given its regulatory role in the immune response and lymphoid tissue development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.
See full target information AFF3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 55: PubMed39791211

2025

Intracellular CIRP promotes liver regeneration via STAT3 signaling pathway activation after partial hepatectomy in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Wang,Mengzhou Wang,Wuming Liu,Lin Zhang,Jia Zhang,Junzhou Zhao,Zheng Wu,Yi Lyu,Rongqian Wu
View all publications
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Product promise

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