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AB177947

Anti-LAGE-1 antibody [EPR12527]

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(2 Publications)

Rabbit Recombinant Monoclonal LAGE-1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

ESO2, LAGE1, CTAG2, Cancer/testis antigen 2, CT2, Autoimmunogenic cancer/testis antigen NY-ESO-2, Cancer/testis antigen 6.2, L antigen family member 1, CT6.2, LAGE-1

1 Images
Western blot - Anti-LAGE-1 antibody [EPR12527] (AB177947)
  • WB

Supplier Data

Western blot - Anti-LAGE-1 antibody [EPR12527] (AB177947)

All lanes:

Western blot - Anti-LAGE-1 antibody [EPR12527] (ab177947) at 1/1000 dilution

Lane 1:

Human melanoma lysate at 10 µg

Lane 2:

Human prostate cancer lysate at 10 µg

Predicted band size: 21 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12527

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LAGE-1 also known as CTAG2 is a cancer/testis antigen that is expressed in tumors and normally only in the testis. Its precise molecular mass is approximately 22 kDa. LAGE-1 plays a mechanical role in cellular processes involving antigen presentation making it significant in the context of immune response modulation within neoplastic environments. The expression profile of LAGE-1 is characterized by its restriction to immune-privileged sites providing an opportunity for tumor-specific interventions due to its limited normal tissue expression.
Biological function summary

LAGE-1 functions as part of a mechanism contributing to tumor immunogenicity. It participates in the presentation of peptides on the surface of cancer cells facilitating their recognition by T cells and subsequent immune targeting. LAGE-1 does not operate in isolation but may interact within a larger complex of similar antigens enhancing the immune system's ability to identify and combat malignancies.

Pathways

The involvement of LAGE-1 in immune surveillance pathways is essential. It interacts with components of the major histocompatibility complex (MHC) class I antigen presentation pathway. By associating with proteins involved in this pathway LAGE-1 enhances the visibility of cancer cells to cytotoxic T lymphocytes. Other proteins such as LAGE-1's homolog MAGE-A share similar pathways suggesting overlapping roles in the formation of antigen complexes and subsequent immune recognition.

LAGE-1 has strong associations with melanoma and non-small cell lung cancer. Its expression in these cancers makes it a target for immunotherapy approaches. In these contexts proteins like NY-ESO-1 which also belongs to the cancer/testis antigen family are co-expressed with LAGE-1 indicating shared roles in tumor progression and immune evasion. These associations underline the potential of LAGE-1 as a marker for targeted cancer immunotherapy strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information CTAG2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:5237 PubMed38898005

2024

Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Victoria O Shender,Ksenia S Anufrieva,Polina V Shnaider,Georgij P Arapidi,Marat S Pavlyukov,Olga M Ivanova,Irina K Malyants,Grigory A Stepanov,Evgenii Zhuravlev,Rustam H Ziganshin,Ivan O Butenko,Olga N Bukato,Ksenia M Klimina,Vladimir A Veselovsky,Tatiana V Grigorieva,Sergey Y Malanin,Olga I Aleshikova,Andrey V Slonov,Nataliya A Babaeva,Lev A Ashrafyan,Elena Khomyakova,Evgeniy G Evtushenko,Maria M Lukina,Zixiang Wang,Artemiy S Silantiev,Anna A Nushtaeva,Daria D Kharlampieva,Vassili N Lazarev,Arseniy I Lashkin,Lorine K Arzumanyan,Irina Yu Petrushanko,Alexander A Makarov,Olga S Lebedeva,Alexandra N Bogomazova,Maria A Lagarkova,Vadim M Govorun

Journal of translational medicine 20:255 PubMed35668458

2022

RAF1 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating LAGE1: an experimental research.

Applications

Unspecified application

Species

Unspecified reactive species

Yanshi Li,Min Pan,Tao Lu,Dan Yu,Chuan Liu,Zhihai Wang,Guohua Hu
View all publications
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