Rabbit Polyclonal Lamin B Receptor/LBR antibody. Suitable for IP, ICC/IF and reacts with Human samples. Cited in 7 publications.
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- Nature communications 12:31762021The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYanyan Chen,Yan Wang,Juan Chen,Wu Zuo,Yong Fan,Sijia Huang,Yongmei Liu,Guangming Chen,Qing Li,Jinsong Li,Jian Wu,Qian Bian,Chenhui Huang,Ming LeiPubMed 34039995
- Molecular cell 81:2216-2230.e102021Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRuben Schep,Eva K Brinkman,Christ Leemans,Xabier Vergara,Robin H van der Weide,Ben Morris,Tom van Schaik,Stefano G Manzo,Daniel Peric-Hupkes,Jeroen van den Berg,Roderick L Beijersbergen,René H Medema,Bas van SteenselPubMed 33848455
- Cancer management and research 12:7501-75142020Exosomal CircGDI2 Suppresses Oral Squamous Cell Carcinoma Progression Through the Regulation of MiR-424-5p/SCAI Axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYu Zhang et. al.PubMed 32943917
- Molecular medicine reports 19:1222-12292018Chrysin protects human osteoarthritis chondrocytes by inhibiting inflammatory mediator expression via HMGB1 suppression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChi Zhang,Weizhong Yu,Chongbo Huang,Qinghe Ding,Chizhang Liang,Le Wang,Zhiqi Hou,Zhiyong ZhangPubMed 30535473
- Human molecular genetics 27:407-4202017TorsinA dysfunction causes persistent neuronal nuclear pore defects.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSamuel S Pappas,Chun-Chi Liang,Sumin Kim,CheyAnne O Rivera,William T DauerPubMed 29186574
- Nature materials 15:1287-12962016Transcription upregulation via force-induced direct stretching of chromatin.Applications:Unspecified applicationReactive species:Unspecified reactive speciesArash Tajik et. al.PubMed 27548707
- Nucleus (Austin, Tex.) 5:318-302014Sequestration within nuclear chromocenters is not a requirement for silencing olfactory receptor transcription in a placode-derived cell line.Applications:IFReactive species:Unspecified reactive speciesSeda Kilinc,Diane T Meredith,Robert P LanePubMed 25482121
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 6 - 8.5
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
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Reactivity data
Select an application| IP | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
IP
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
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Target data
Function
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722, PubMed:9630650). Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity). Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963).
Alternative names
Delta(14)-sterol reductase LBR, Delta-14-SR, 3-beta-hydroxysterol Delta (14)-reductase, C-14 sterol reductase, Integral nuclear envelope inner membrane protein, LMN2R, Lamin-B receptor, Sterol C14-reductase, C14SR, LBR
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Rabbit Polyclonal Lamin B Receptor/LBR antibody. Suitable for IP, ICC/IF and reacts with Human samples. Cited in 7 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 6 - 8.5
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
ab122919 is affinity purified using recombinant immunogen.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Lamin B Receptor (LBR) also known as L. B. R. L B R or lamin B is a protein located in the inner nuclear membrane. This protein has a molecular mass of approximately 70 kDa. It acts as a receptor for lamin proteins specifically lamin B. The LBR mediates the attachment of heterochromatin and lamins to the inner nuclear membrane playing a structural role in the maintenance of nuclear architecture. It is widely expressed in various tissues notably in cells involved in rapidly proliferating tissues.
- Biological function summary
The LBR protein serves several critical functions beyond its mechanical duties. It participates in the regulation of chromatin organization and gene expression owing to its interaction with chromatin-related proteins. LBR is part of the nuclear envelope lattice and forms complexes with lamin proteins and heterochromatin. This association supports its role in anchoring chromatin at the nuclear periphery modulating processes such as DNA replication and transcription.
- Pathways
The LBR plays pivotal roles in nuclear envelope assembly and chromatin organization. It holds significance in the cholesterol biosynthesis pathway where it metabolizes sterol intermediates to cholesterol. This function relates LBR to other proteins including lamin A/C which collaborate in maintaining nuclear shape and function. Together they orchestrate various cellular processes important for cell cycle progression and differentiation.
- Associated diseases and disorders
Alterations in LBR function have links to conditions such as Pelger-Huët anomaly and Greenberg skeletal dysplasia. Pelger-Huët anomaly manifests as a benign hematologic condition with defective nuclear shape in neutrophils while Greenberg dysplasia is characterized by skeletal abnormalities. In these contexts LBR connects to lamin B and other nuclear envelope proteins that contribute to the pathophysiological features observed in these disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunoprecipitation - Anti-Lamin B Receptor/LBR antibody (ab122919)
Identification of Lamin B Receptor/LBR in crude extract of HeLa cells by immuno-precipitation using ab122919, followed by Western blotting.
All lanes: Immunoprecipitation - Anti-Lamin B Receptor/LBR antibody (ab122919)
Predicted band size: 71 kDa
Immunocytochemistry/ Immunofluorescence - Anti-Lamin B Receptor/LBR antibody (ab122919)
Indirect immuno-fluorescence staining of HeLa cells using ab122919.
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