Anti-Laminin antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Laminin also known as Laminin-1 is a high-molecular weight protein with a mass of approximately 400 to 900 kDa. It belongs to the family of heterotrimeric glycoproteins found in the extracellular matrix specifically within the basement membranes. This protein includes several isoforms referred to as laminins which consist of three distinct chains: α, β and γ. Laminins contribute to the structural scaffolding by interacting with other molecules like collagen and integrins playing a significant role in tissue architecture and cellular activities such as adhesion and migration. Researchers focus on targeting laminin with laminin antibodies for experiments like laminin IHC and laminin staining to visualize and study tissue structures.

Biological function summary

Laminins serve as essential components in maintaining tissue integrity and functions. They form complexes with other matrix elements to establish basement membranes which separate epithelial cells from connective tissue. Laminins interact with cellular receptors influencing cell differentiation movement and growth. Anti-laminin tools like laminin antibodies and laminin staining techniques help identify specific isoforms and analyze their distribution in research. Scientists often utilize laminine products for such purposes including insights into how they might regulate cellular environments through these complexes.

Pathways

Laminins integrate into essential biological pathways including the PI3K/Akt and MAPK pathways. Through these pathways laminins directly influence cellular processes such as proliferation and survival. They work in tandem with proteins like integrins and collagen reinforcing the structural and signaling pathways necessary for controlling cell fate. These interactions place laminins at the center of cellular communication networks regulating various developmental and physiological processes.

Associated diseases and disorders

Laminins have connections to several medical conditions including muscular dystrophy and certain forms of cancer. Abnormalities in laminin expression or structure can lead to defective basement membranes contributing to genetic disorders like congenital muscular dystrophy. Laminins also interact with collagen another protein involved in maintaining tissue integrity making their dysfunction a point of interest in oncological research. Scientists in laminine UK and globally use anti-laminin technologies to understand laminin's role in pathogenesis aiming to develop targeted therapies.