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Rabbit Polyclonal LANCL1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LANCL1 aa 100 to C-terminus.

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Images

Western blot - Anti-LANCL1 antibody (AB151290), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL1 antibody (AB151290), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human LANCL1 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O43813

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-PWB
Human
Tested
Tested
Mouse
Predicted
Predicted
Rat
Predicted
Predicted

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/1000.00000

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Predicted
Predicted

Species

Mouse, Rat

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/3000.00000

Notes

-

Predicted
Predicted

Species

Mouse, Rat

Dilution info

-

Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316).

Alternative names

Recommended products

Rabbit Polyclonal LANCL1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LANCL1 aa 100 to C-terminus.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human LANCL1 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O43813
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

LANCL1 also known as Lanthionine synthetase component C-like protein 1 is a protein present in the cell and has a mass of approximately 47 kDa. This protein shows expression in various tissues including the brain and adipose tissue. It belongs to the larger LANCL protein family and shows sequence homology with other family members. LANCL1 works intracellularly binding and modulating the activity of different molecules which could influence various cell processes.

Biological function summary

The LANCL1 protein interacts with several intracellular proteins. It might not act alone but rather as part of a multiprotein complex which suggests a role in complex cellular mechanisms. LANCL1's activity affects cellular maintenance and growth. It helps in the regulation of oxidative stress responses by directly impacting key cellular regulators of redox state.

Pathways

The LANCL1 protein plays a role in the oxidative stress response pathway and energy metabolism pathway. It modulates cellular responses to oxidative stress and interacts with proteins such as NRF2 which is important for the antioxidant response. Furthermore it has a potential connection with pathways linked to energy homeostasis aligning with its expression in adipose tissue where it could interact with metabolic proteins like AMPK.

Associated diseases and disorders

LANCL1 has associations with neurodegenerative diseases and obesity. Aberrant regulation of LANCL1 protein might lead to increased oxidative stress contributing to conditions such as Alzheimer's disease where it could potentially influence the activity of the protein amyloid-beta. Additionally its role in energy metabolism links it to obesity where it might affect proteins critical in lipid storage and adipose tissue function.

Product promise

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2 product images

  • Western blot - Anti-LANCL1 antibody (ab151290), expandable thumbnail

    Western blot - Anti-LANCL1 antibody (ab151290)

    10% SDS PAGE

    All lanes: Western blot - Anti-LANCL1 antibody (ab151290) at 1/1000 dilution

    All lanes: HeLa whole cell lysate at 30 µg

    Predicted band size: 45 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL1 antibody (ab151290), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL1 antibody (ab151290)

    Immunohistochemical analysis of paraffin-embedded Human colon carcinoma tissue labeling LANCL1 with ab151290 at 1/250 dilution.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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