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AB229257

Anti-LANCL1 antibody

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(1 Publication)

Rabbit Polyclonal LANCL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LANCL1.

View Alternative Names

GPR69A, LANCL1, Glutathione S-transferase LANCL1, 40 kDa erythrocyte membrane protein, LanC-like protein 1, p40

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL1 antibody (AB229257)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL1 antibody (AB229257)

Paraffin-embedded U87 xenograft tissue stained for LANCL1 with ab229257 at 1/500 dilution in immunohistochemical analysis.

Western blot - Anti-LANCL1 antibody (AB229257)
  • WB

Supplier Data

Western blot - Anti-LANCL1 antibody (AB229257)

10% SDS-PAGE

All lanes:

Western blot - Anti-LANCL1 antibody (ab229257) at 1/1000 dilution

Lane 1:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 30 µg

Lane 2:

Raji (human Burkitt's lymphoma cell line) whole cell lysate at 30 µg

Predicted band size: 45 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human LANCL1. The exact immunogen used to generate this antibody is proprietary information.

O43813

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LANCL1 also known as Lanthionine synthetase component C-like protein 1 is a protein present in the cell and has a mass of approximately 47 kDa. This protein shows expression in various tissues including the brain and adipose tissue. It belongs to the larger LANCL protein family and shows sequence homology with other family members. LANCL1 works intracellularly binding and modulating the activity of different molecules which could influence various cell processes.
Biological function summary

The LANCL1 protein interacts with several intracellular proteins. It might not act alone but rather as part of a multiprotein complex which suggests a role in complex cellular mechanisms. LANCL1's activity affects cellular maintenance and growth. It helps in the regulation of oxidative stress responses by directly impacting key cellular regulators of redox state.

Pathways

The LANCL1 protein plays a role in the oxidative stress response pathway and energy metabolism pathway. It modulates cellular responses to oxidative stress and interacts with proteins such as NRF2 which is important for the antioxidant response. Furthermore it has a potential connection with pathways linked to energy homeostasis aligning with its expression in adipose tissue where it could interact with metabolic proteins like AMPK.

LANCL1 has associations with neurodegenerative diseases and obesity. Aberrant regulation of LANCL1 protein might lead to increased oxidative stress contributing to conditions such as Alzheimer's disease where it could potentially influence the activity of the protein amyloid-beta. Additionally its role in energy metabolism links it to obesity where it might affect proteins critical in lipid storage and adipose tissue function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed : 19528316).
See full target information LANCL1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

eLife 9: PubMed32352376

2020

DASC, a sensitive classifier for measuring discrete early stages in clathrin-mediated endocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Xinxin Wang,Zhiming Chen,Marcel Mettlen,Jungsik Noh,Sandra L Schmid,Gaudenz Danuser
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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