JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB272583

Anti-LANCL2 antibody

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Polyclonal LANCL2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human LANCL2 aa 200-300.

View Alternative Names

GPR69B, TASP, LANCL2, LanC-like protein 2, Testis-specific adriamycin sensitivity protein

6 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL2 antibody (AB272583)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL2 antibody (AB272583)

Paraffin-embedded formalin-fixed Human liver tissue stained for LANCL2 using ab272583 at 1/200 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL2 antibody (AB272583)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL2 antibody (AB272583)

Paraffin-embedded formalin-fixed Human cerebral cortex tissue stained for LANCL2 using ab272583 at 1/200 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL2 antibody (AB272583)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL2 antibody (AB272583)

Paraffin-embedded formalin-fixed Human prostate tissue stained for LANCL2 using ab272583 at 1/200 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL2 antibody (AB272583)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LANCL2 antibody (AB272583)

Paraffin-embedded formalin-fixed Human testis tissue stained for LANCL2 using ab272583 at 1/200 in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-LANCL2 antibody (AB272583)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-LANCL2 antibody (AB272583)

PFA fixed, Triton X-100 permeablized human cell line U-2 OS labeling LANCL2 (green) using ab272583 at 2 ug/ml in ICC/IF analysis.

Western blot - Anti-LANCL2 antibody (AB272583)
  • WB

Unknown

Western blot - Anti-LANCL2 antibody (AB272583)

Lane 1:

Western blot - Anti-LANCL2 antibody (ab272583)

Lanes 2 - 3:

Western blot - Anti-LANCL2 antibody (ab272583) at 0.4 µg/mL

Lane 1:

Molecular weight ladder

Lane 2:

Control (vector only transfected HEK-293T lysate)

Lane 3:

LANCL2 over-expression lysate (mammalian HEK-293T cells)

Predicted band size: 51 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human LANCL2 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.

Q9NS86

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LANCL2 also known as Lanthionine Synthetase C-Like 2 is a protein with a molecular weight of approximately 44 kDa. It belongs to the LANCL protein family which also includes LANCL1 and LANCL3. LANCL2 is expressed in various tissues with significant expression observed in adipose tissue liver and skeletal muscle. Its intracellular location suggests a role in cellular processes that require close interaction with intracellular signaling pathways.
Biological function summary

LANCL2 functions in regulatory mechanisms related to metabolic processes. It does not exist in isolation; instead it interacts with other proteins as part of a multiprotein complex. LANCL2 modulates the signaling pathway involving the peroxisome proliferator-activated receptor gamma (PPARγ) and plays a role in modulating glucose and lipid metabolism. Its activity suggests involvement in maintaining cellular energy balance and homeostasis.

Pathways

LANCL2 is integrated into metabolic pathways with significant involvement in both the PPAR signaling pathway and the insulin signaling pathway. These pathways highlight its importance in glucose homeostasis and energy metabolism. LANCL2 interacts with proteins such as AKT an important player in the insulin signaling pathway contributing to the regulation of glucose uptake and lipid metabolism.

LANCL2 has been connected to metabolic diseases particularly type 2 diabetes and obesity. Changes in LANCL2 expression or function can impact glucose and lipid regulation contributing to these conditions. LANCL2's role in these disorders often involves its interaction with proteins like PPARγ which also influences lipid storage and insulin sensitivity. Understanding LANCL2's role in these diseases could provide insights into novel therapeutic approaches.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
See full target information LANCL2
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB181105

Anti-USP4 antibody [EPR13846]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-USP4 antibody [EPR13846] (AB181105)

  • 0
  • 0
Primary Antibodies

AB262879

Anti-ZRANB1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZRANB1 antibody (AB262879)

  • 0
  • 0
Primary Antibodies

AB272576

Anti-TOX4 antibody

Immunocytochemistry/ Immunofluorescence - Anti-TOX4 antibody (AB272576)

  • 0
  • 0
Primary Antibodies

AB236887

Anti-TPPP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPPP2 antibody (AB236887)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com