JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB127568

Anti-Lano antibody

Be the first to review this product! Submit a review

|

(3 Publications)

Rabbit Polyclonal Lano antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LRRC1 aa 250 to C-terminus.

View Alternative Names

LANO, LRRC1, Leucine-rich repeat-containing protein 1, LANO adapter protein, LAP and no PDZ protein

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lano antibody (AB127568)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lano antibody (AB127568)

ab127568, at 1/250 dilution, staining Lano in paraffin embedded Human breast carcinoma tissue by Immunohistochemistry.

Western blot - Anti-Lano antibody (AB127568)
  • WB

Unknown

Western blot - Anti-Lano antibody (AB127568)

7.5% SDS PAGE

All lanes:

Western blot - Anti-Lano antibody (ab127568) at 1/1000 dilution

All lanes:

HCT116 whole cell lysate at 30 µg

Predicted band size: 59 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human LRRC1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BTT6

style
left-column

Complementary Products

Primary Antibodies

AB8227

Anti-beta Actin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-beta Actin antibody - Loading Control (AB8227)

  • 5
  • 104
Primary Antibodies

AB7291

Anti-alpha Tubulin antibody [DM1A] - Loading Control

BOND RX™ Validated

Western blot - Anti-alpha Tubulin antibody [DM1A] - Loading Control (AB7291)

  • 5
  • 92
Primary Antibodies

AB247016

Anti-VPS36 antibody

Immunocytochemistry/ Immunofluorescence - Anti-VPS36 antibody (AB247016)

  • 0
  • 0
Primary Antibodies

AB96551

Anti-MAP4K5 antibody

Immunocytochemistry/ Immunofluorescence - Anti-MAP4K5 antibody (AB96551)

  • 4
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Lano also known as Lanolin-associated protein is a protein that has a molecular mass of approximately 25 kDa. It is expressed mainly in tissues such as the epidermis and sebaceous glands. This protein plays a role in structural integrity and cellular interactions. Its expression patterns suggest involvement in skin physiology and maintenance where it contributes to cellular cohesion and structural support.
Biological function summary

Lano functions as a part of protein complexes that facilitate cellular adhesion and interaction within skin tissue. These complexes are critical in maintaining skin barrier properties and preventing transepidermal water loss. By interacting with different skin structural proteins Lano contributes to skin's resilience and repair mechanisms supporting its role in physical barrier maintenance.

Pathways

Researchers have linked Lano to the epidermal differentiation pathway an important process in skin development and repair. Lano associates with proteins such as Filaggrin and Involucrin which play critical roles in keratinocyte differentiation and maturation. These proteins work together in a coordinated manner forming complexes that contribute to the formation of the skin barrier.

Lano has shown associations with dermatological conditions such as eczema and psoriasis. In these diseases protein interactions involving Lano particularly with Filaggrin may become dysregulated leading to compromised skin barrier functions and increased susceptibility to allergens and infections. Understanding Lano’s role in these conditions may provide insight into new therapeutic strategies for managing skin-related disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information LRRC1
style
left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of virology 98:e0125823 PubMed38546211

2024

Exploring the therapeutic potential of DV-B-120 as an inhibitor of dengue virus infection.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Jung Huang,Tian-Lu Cheng,Yen-Tseng Wang,Chien-Shu Chen,Yu-Ling Leu,Chih-Shiang Chang,Cheng-Han Ho,Shi-Wei Chao,Chia-Tse Li,Chih-Hung Chuang

Aging 15:7637-7654 PubMed37543430

2023

TMT-based quantitative proteomic analysis revealed that FBLN2 and NPR3 are involved in the early osteogenic differentiation of mesenchymal stem cells (MSCs).

Applications

Unspecified application

Species

Unspecified reactive species

Jianyun Liu,Shan He,Baicheng Ma,Xingnuan Li,Yaqin Wang,Jianjun Xiong

Molecular and cellular biochemistry 478:1465-1473 PubMed36370237

2022

The downstream PPARγ target LRRC1 participates in early stage adipocytic differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Xinping Wang,Jianyun Liu,Ting Wang,Baicheng Ma,Ping Wu,Xiaoyuan Xu,Jianjun Xiong
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com