Anti-LAP2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The LAP2 protein also known as Lamin-Associated Polypeptide 2 plays a significant role in the structural organization of the nuclear envelope. This protein exists in various isoforms with LAP2β being among the most studied. LAP2 has a molecular mass ranging from 45 to 80 kDa depending on its isoform. LAP2 shows expression in nuclear membrane and endoplasmic reticulum and these locations enable it to participate in the anchorage of chromatin and nuclear lamina to the inner nuclear membrane.

Biological function summary

The LAP2 protein acts as a scaffold for several nuclear processes. It interacts with lamin proteins forming complexes that are vital for both nuclear assembly and structural stability. Through these interactions LAP2 not only assists in maintaining nuclear shape but also plays a role in DNA replication and gene expression regulation. By facilitating interactions between chromatin and the inner nuclear membrane LAP2 influences the spatial organization of genetic material within the nucleus.

Pathways

The LAP2 protein engages in the regulation of key cellular processes such as the cell cycle and apoptosis. In the context of the cell cycle LAP2 associates with nuclear lamins and other nuclear envelope components impacting the dynamic disassembly and reassembly of the nuclear envelope during mitosis. In apoptosis pathways LAP2 interacts with proteins like BAF (Barrier-to-Autointegration Factor) affecting chromatin condensation and DNA fragmentation phases.

Associated diseases and disorders

LAP2 protein alterations show connections to cardiac and muscular pathologies. Mutations or dysregulation of LAP2 protein can contribute to Emery-Dreifuss muscular dystrophy a condition often linked with mutant nuclear envelope proteins including emerin and lamins. Additionally LAP2 has relevance in dilated cardiomyopathy where its interaction with lamin A/C becomes impaired leading to improper nuclear structural integrity and function.