Anti-Large subunit of NADH-dependent glutamate synthase antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The large subunit of NADH-dependent glutamate synthase also known as GltB participates in the conversion of glutamine and 2-oxoglutarate to glutamate. This enzyme plays a role in nitrogen assimilation and has a molecular mass of approximately 150 kDa. The large subunit of NADH-dependent glutamate synthase is mostly found in the chloroplasts of plants and cyanobacteria though it can also appear in certain bacteria where it aids in essential metabolic activities.

Biological function summary

The large subunit engages in forming glutamate which is a fundamental amino acid in many organisms. It acts as part of a protein complex where it joins with a small subunit (GltD) to complete its enzymatic function. This protein complex ensures the efficient transfer of nitrogen within the organism contributing to amino acid biosynthesis and cellular growth functions.

Pathways

The large subunit of NADH-dependent glutamate synthase plays an essential part in the nitrogen cycle and glutamate metabolism. The enzyme interacts within the pathway alongside proteins like glutamine synthetase facilitating the conversion of ammonia to amino acids. This pathway involvement highlights its roles in metabolite interconversion and energy cycling in cells.

Associated diseases and disorders

Disruptions in the function of this large subunit of glutamate synthase could lead to issues in nitrogen metabolism such as metabolic syndromes in plants or cyanobacteria. Proteins like glutamate decarboxylase link to this target under pathological conditions where imbalanced glutamate levels could contribute to neurological disorders. Understanding these interactions helps researchers target pathways in agricultural or microbial settings aiming to improve growth efficiency and health.