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AB238763

Anti-LARP6 antibody

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(1 Publication)

Rabbit Polyclonal LARP6 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LARP6 aa 250-500.

View Alternative Names

La-related protein 6, Acheron, La ribonucleoprotein domain family member 6, Achn, LARP6

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LARP6 antibody (AB238763)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LARP6 antibody (AB238763)

Paraffin-embedded human adrenal gland tissue stained for LARP6 using ab238763 at 1/200 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LARP6 antibody (AB238763)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LARP6 antibody (AB238763)

Paraffin-embedded human appendix tissue stained for LARP6 using ab238763 at 1/200 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LARP6 aa 250-500. The exact immunogen used to generate this antibody is proprietary information.

Q9BRS8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LARP6 or La-related protein 6 is a member of the LARP family that plays a mechanical role in RNA-binding activities. It has a mass of about 63 kDa. LARP6 is expressed in various tissues with higher levels observed in the liver heart and skeletal muscle. Its main function is binding to specific messenger RNA (mRNA) motifs to regulate the stability and translation of these mRNAs.
Biological function summary

LARP6 is involved in the regulation of protein synthesis particularly influencing collagen biosynthesis. It often functions as part of a complex that binds to the 5' stem-loop structure of collagen mRNAs which helps stabilize them and facilitates their translation. LARP6 ensures the proper production of collagen proteins important for maintaining structural integrity in tissues.

Pathways

LARP6 functions within the collagen biosynthesis and secretion pathway. It closely interacts with proteins such as ribosome components to enhance mRNA translation efficiency. In the context of mRNA regulation LARP6 is significant for the post-transcriptional control of collagen production involving coordination with other RNA-binding proteins to affect the ribosomal engagement of target mRNAs.

LARP6 has been linked to fibrosis and certain connective tissue disorders. Abnormal expression or malfunction of LARP6 can lead to altered collagen synthesis contributing to disease progression. In fibrotic conditions disrupted LARP6 activity can impact collagen production pathways potentially interacting with proteins such as fibronectin which plays a role in extracellular matrix composition. Understanding LARP6's function and regulation could provide insights into treatments for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.
See full target information LARP6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Middle East journal of digestive diseases 12:39-44 PubMed32082520

2020

Assessment of Immuno-Histochemical Expression of MBD1 in Colorectal Adenocarcinoma and Its Correlations with Prognostic Factors.

Applications

Unspecified application

Species

Unspecified reactive species

Sholeh Ghaedamini,Mehdi Nikbakht,Mitra Soleimani
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Product promise

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