Rabbit Polyclonal LARP7 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human LARP7 aa 500 to C-terminus.
View Alternative Names
HDCMA18P, LARP7, La-related protein 7, La ribonucleoprotein domain family member 7, P-TEFb-interaction protein for 7SK stability, hLARP7, PIP7S
- IP
Unknown
Immunoprecipitation - Anti-LARP7 antibody (AB134757)
Lane 1 : Immunoprecipitation from HeLa whole cell lysate (1 mg for IP, 20% of IP loaded), using an antibody which recognized an upstream epitope of LARP7.
Lane 2 : Detection of Human LARP7 by Immunoprecipitation from HeLa whole cell lysate (1 mg for IP, 20% of IP loaded), using ab134757 at 6 µg/mg lysate for IP.
Lane 3 : Immunoprecipitation from HeLa whole cell lysate (1 mg for IP, 20% of IP loaded), using Control IgG.
Subsequent Western blot detection used ab134757 at 1 µg/ml.
Gel concentration 4-20%
Developed using the ECL technique with an exposure time of 10 seconds.
All lanes:
Immunoprecipitation - Anti-LARP7 antibody (ab134757)
Predicted band size: 66 kDa
false
- WB
Unknown
Western blot - Anti-LARP7 antibody (AB134757)
Gel concentration 4-20%
All lanes:
Western blot - Anti-LARP7 antibody (ab134757) at 0.1 µg/mL
Lane 1:
Whole cell lysate from HeLa cells at 50 µg
Lane 2:
Whole cell lysate from HeLa cells at 15 µg
Lane 3:
Whole cell lysate from 293T cells at 50 µg
Lane 4:
Whole cell lysate from Jurkat cells at 50 µg
Lane 5:
Whole cell lysate from mouse NIH3T3 cells at 50 µg
Predicted band size: 66 kDa
true
Exposure time: 30s
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- 0
- 0
Reactivity data
Properties and storage information
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Appropriate long-term storage conditions
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
LARP7 stabilizes the 7SK snRNA which forms part of a multiprotein complex that regulates transcription elongation. This complex controls the activity of positive transcription elongation factor b (P-TEFb) a critical component in managing RNA polymerase II transcription. Through its interaction with the 7SK snRNP complex LARP7 helps regulate gene expression by controlling transcription elongation and maintaining proper cellular function.
Pathways
LARP7 plays a significant role in the regulation of gene expression and transcription elongation pathways. It directly interacts with P-TEFb impacting the control of transcriptional elongation factors. LARP7's function in these pathways highlights its relationship with transcription-related proteins highlighting its integrative role in managing cellular transcription processes.
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Target data
Publications (3)
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eLife 9: PubMed32048991
2020
Applications
Unspecified application
Species
Unspecified reactive species
Molecular cell 77:999-1013.e6 PubMed32017896
2020
Applications
Unspecified application
Species
Unspecified reactive species
Cell reports 29:2229-2242.e4 PubMed31747597
2019
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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