Anti-Lassa virus Nucleoprotein antibody [HL1390]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

LASV NP also known as Lassa virus nucleoprotein or NP is a structural protein with a mass of approximately 63 kDa. It plays an important role in the replication cycle of Lassa virus a member of the Arenaviridae family. Expressed primarily in infected host cells NP assists in the formation of viral ribonucleoprotein complexes. This protein encapsidates the viral RNA genome safeguarding it from degradation and interacting with the viral polymerase which is necessary for efficient viral replication and transcription.

Biological function summary

This nucleoprotein serves a multifunctional role in viral propagation and immune evasion. In addition to its RNA-binding properties NP suppresses the host's innate immune responses by interfering with interferon signaling pathways. It accomplishes this by degrading double-stranded RNA thereby preventing activation of the pathway. NP is not known to be part of a larger complex but operates closely with other viral components to enhance viral survival and replication within host cells.

Pathways

LASV NP is implicated importantly in the viral life cycle and immune evasion mechanisms. The interferon signaling pathway is significantly impacted by NP's ability to counteract interferon responses which normally aid in defense against viral infections. NP cooperates with the Lassa virus glycoprotein complex and matrix protein in these pathways coordinating processes that facilitate successful viral replication and assembly while concurrently subverting host immune defenses.

Associated diseases and disorders

LASV NP is closely associated with Lassa fever a severe viral hemorrhagic illness endemic in parts of West Africa. The NP's role in immune system modulation connects it with an increased virulence of the virus therefore contributing to the pathogenesis of Lassa fever. Additionally interactions between NP and the host immune-modulating proteins such as those in the interferon family influence the disease progression and host immune response making it a target of interest for antiviral therapies.