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AB169337

Anti-LCMT1 antibody

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(1 Publication)

Rabbit Polyclonal LCMT1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LCMT1.

View Alternative Names

LCMT, CGI-68, LCMT1, Leucine carboxyl methyltransferase 1, Protein-leucine O-methyltransferase, [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1

1 Images
Western blot - Anti-LCMT1 antibody (AB169337)
  • WB

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Western blot - Anti-LCMT1 antibody (AB169337)

All lanes:

Western blot - Anti-LCMT1 antibody (ab169337) at 1 µg/mL

Lane 1:

LCMT1-transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 38 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human LCMT1.

Q9UIC8

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LCMT1 also known as leucine carboxyl methyltransferase 1 is an enzyme with a mass of approximately 25 kDa. This enzyme plays an important role in the methylation of the C-terminal leucine residues of proteins specifically targeting protein phosphatase 2A (PP2A). It methylates the PP2A catalytic subunit affecting its activity and interactions. LCMT1 expression occurs widely in tissues with high expression noted in the brain and testis.
Biological function summary

This enzyme contributes to the dynamic regulation of protein phosphatase activity within cells. LCMT1 operates as part of a complex with PP2A and influences the formation of PP2A holoenzymes. By methylating the catalytic subunit of PP2A LCMT1 impacts the holoenzyme's substrate specificity and enzymatic activity contributing to cellular signaling and homeostasis.

Pathways

LCMT1 activity integrates into the regulation of various signaling cascades notably the MAPK and AKT pathways. These pathways are important for cell growth survival and differentiation. LCMT1 influences these pathways by modulating PP2A activity which can dephosphorylate key signaling molecules such as ERK and AKT. LCMT1 works in concert with other proteins like PME-1 that demethylate PP2A to fine-tune this regulation.

LCMT1 has connections to neurodegenerative diseases and certain cancers. In neurodegenerative diseases such as Alzheimer's disease altered LCMT1 activity can lead to dysregulation of PP2A which affects tau phosphorylation and accumulation. Moreover in cancer such as hepatocellular carcinoma LCMT1's regulation of PP2A can influence cellular proliferation and apoptosis. It interacts functionally with proteins like alpha4 which is associated with PP2A and involved in their pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
See full target information LCMT1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cells 12: PubMed37626836

2023

Effect of Vitamin D on Chemerin and Adiponectin Levels in Uterus of Polycystic Ovary Syndrome Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Karolina Pich,Jesika Rajewska,Kinga Kamińska,Marcelina Tchurzyk,Agata Szlaga,Patryk Sambak,Anna Błasiak,Małgorzata Grzesiak,Agnieszka Rak
View all publications
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Product promise

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