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AB232995

Anti-LCN1 antibody

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(1 Publication)

Rabbit Polyclonal LCN1 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LCN1 aa 1 to C-terminus.

View Alternative Names

VEGP, LCN1, Lipocalin-1, Tear lipocalin, Tear prealbumin, von Ebner gland protein, Tlc, TP, VEG protein

4 Images
Western blot - Anti-LCN1 antibody (AB232995)
  • WB

Supplier Data

Western blot - Anti-LCN1 antibody (AB232995)

All lanes:

Western blot - Anti-LCN1 antibody (ab232995) at 1 µg/mL

All lanes:

Human urine

Predicted band size: 19 kDa

true

Western blot - Anti-LCN1 antibody (AB232995)
  • WB

Supplier Data

Western blot - Anti-LCN1 antibody (AB232995)

All lanes:

Western blot - Anti-LCN1 antibody (ab232995) at 1 µg/mL

All lanes:

Recombinant human LCN1

Predicted band size: 19 kDa

true

Western blot - Anti-LCN1 antibody (AB232995)
  • WB

Supplier Data

Western blot - Anti-LCN1 antibody (AB232995)

All lanes:

Western blot - Anti-LCN1 antibody (ab232995) at 1 µg/mL

All lanes:

Human saliva

Predicted band size: 19 kDa

true

Western blot - Anti-LCN1 antibody (AB232995)
  • WB

Supplier Data

Western blot - Anti-LCN1 antibody (AB232995)

All lanes:

Western blot - Anti-LCN1 antibody (ab232995) at 1 µg/mL

All lanes:

Rat tongue tissue lysate

Predicted band size: 19 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human LCN1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P31025

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Complementary Products

Assay Kits

AB313984

Human LCN1 ELISA Kit

Sandwich ELISA - Human LCN1 ELISA Kit (AB313984)

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Proteins & Peptides

AB276407

Recombinant Human LCN1 protein (His tag)

SDS-PAGE - Recombinant Human LCN1 protein (His tag) (AB276407)

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Assay Kits

AB313984

Human LCN1 ELISA Kit

Sandwich ELISA - Human LCN1 ELISA Kit (AB313984)

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  • 0
Primary Antibodies

AB188329

Anti-TXNDC11/EFP1 antibody [EPR14314] - C-terminal

RabMAb|Recombinant

Immunoprecipitation - Anti-TXNDC11/EFP1 antibody [EPR14314] - C-terminal (AB188329)

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Primary Antibodies

AB178696

Anti-TSEN54 antibody [EPR10062]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-TSEN54 antibody [EPR10062] (AB178696)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LCN1 also known as Lipocalin-1 or tear lipocalin is a secreted protein with a mass of approximately 21 kDa. It primarily localizes in human tears and other secretions including saliva. This protein belongs to the lipocalin family known for their small size and ability to bind hydrophobic molecules. Its key function includes transporting small lipophilic molecules such as fatty acids and retinoids contributing to ocular surface health.
Biological function summary

LCN1 plays an essential role in protecting the eye's surface. It binds and neutralizes bacteria-derived lipopolysaccharides which helps to control microbial growth on the eye surface. LCN1 may interact with other components present in tear film but it does not form a complex with them. The protein participates in transporting molecules across cell membranes and modulating the immune response at ocular and oral sites.

Pathways

LCN1 has a significant role in the defense mechanisms of the tear film. It engages in the immune response pathway helping to maintain homeostasis in the ocular surface microenvironment. Its binding capabilities are related to fatty acid transport pathways. LCN1 indirectly interacts with proteins related to lipid transport such as albumin due to its role in managing lipid interactions at epithelial surfaces.

LCN1 shows a connection to dry eye syndrome a condition resulting from insufficient tear production or quality leading to inflammation and damage to the eye surface. The protein also relates to Sjögren’s syndrome an autoimmune disorder affecting moisture-producing glands. These associations arise because LCN1's deficiency or dysfunction can contribute to the pathology observed in these disorders alongside proteins like lactoferrin which is also important in tear film stability and ocular health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.
See full target information LCN1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

European journal of medical research 29:498 PubMed39415292

2024

The deubiquitinase OTUD3 stabilizes IRP2 expression to reduce hippocampal neuron ferroptosis via the p53/PTGS2 pathway to ameliorate cerebral ischemia-reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Hou,Yujie Hu,Tian Yun,Hongxin Li,Guoshuai Yang,Dan Yu
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Product promise

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