AB14519

Anti-LDL (Copper oxidized) antibody

(2 Reviews)

(11 Publications)

Rabbit Polyclonal LDL (Copper oxidized) antibody. Suitable for ELISA, IHC-P and reacts with Human samples. Cited in 11 publications.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ELISA

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LDL (Copper oxidized) also known as oxidized copper is a type of low-density lipoprotein modified through oxidation processes involving copper ions. LDL with an approximate mass of 2.2 to 3.0 MDa is primarily expressed in the bloodstream and synthesized in the liver. While standard LDL plays a role in lipid transport the oxidized form exhibits altered mechanical properties including greater uptake by macrophages leading to foam cell formation.

Biological function summary

The oxidized form of LDL has a significant role in atherosclerosis progression. Oxidized LDL is not part of a distinct complex but interacts with cells through scavenger receptors like SR-A and CD36 on macrophages prompting inflammatory responses. The oxidative modification occurs when copper ions catalyze the formation of lipid peroxides enhancing the inflammatory potential of LDL.

Pathways

Oxidized LDL acts within the inflammation and lipid metabolism pathways. It contributes to the Toll-like receptor signaling pathway which mediates inflammatory responses and the cholesterol metabolism pathway. Proteins closely related to these pathways include apolipoprotein B-100 which is integral to LDL structure and CEPT an enzyme involved in lipid exchange and transport reactions.

Oxidized LDL has strong associations with atherosclerosis and cardiovascular disease. Its presence in the vascular endothelium induces injury and plaque formation pathways that involve key proteins like matrix metalloproteinases (MMPs) and interleukin-6 (IL-6). Oxidized LDL also links to hyperlipidemia where it exacerbates the risk by promoting endothelial dysfunction and inflammatory signaling creating a feedback loop that further elevates cardiovascular risk.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information LDL (Copper oxidized)

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 13:865704 PubMed35619689

2022

Topical Simvastatin Improves Lesions of Diffuse Normolipemic Plane Xanthoma by Inhibiting Foam Cell Pyroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Siyuan Zha,Xia Yu,Xiaoxiao Wang,Yan Gu,Yidong Tan,Ying Lu,Zhirong Yao

Molecular medicine reports 24: PubMed34036387

2021

LDL‑induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Wang,Wenbo Zhang,Zhen Feng,Jian Zhang,Ying Sun,Wei Zhang

Cell death & disease 11:626 PubMed32796811

2020

Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Jing,Ning Ding,Dandan Wang,Xie Ge,Jinzhao Ma,Rujun Ma,Xuan Huang,Kadiliya Jueraitetibaike,Kuan Liang,Shuxian Wang,Siyuan Cao,Allan Zijian Zhao,Bing Yao

BioMed research international 2019:3514574 PubMed31534958

2019

FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Zhang,Tingli Wang,Qinhua Yin,Junlin Zhang,Li Li,Ruikun Guo,Qianqian Han,Hanyu Li,Yiting Wang,Jiali Wang,Pramesh Gurung,Yanrong Lu,Jingqiu Cheng,Lin Bai,Jie Zhang,Fang Liu

JCI insight 4: PubMed31391342

2019

An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine Redinus,Jin Hyen Baek,Ayla Yalamanoglu,Hye Kyung H Shin,Radu Moldova,Julie W Harral,Delaney Swindle,David Pak,Scott K Ferguson,Rachelle Nuss,Kathryn Hassell,Eva Nozik-Grayck,Andre F Palmer,Mehdi A Fini,Vijaya Karoor,Kurt R Stenmark,Paul W Buehler,David C Irwin

Bioscience reports 38: PubMed29789399

2018

gene polymorphism and its interaction with smoking and drinking on the risk of coronary artery disease for Chinese patients.

Applications

Unspecified application

Species

Unspecified reactive species

Yongjun Ying,Yuxuan Luo,Hui Peng

American journal of physiology. Gastrointestinal and liver physiology 300:G71-81 PubMed21030611

2010

Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins.

Applications

Unspecified application

Species

Unspecified reactive species

Ruomei Li,Ana Oteiza,Karen Kristine Sørensen,Peter McCourt,Randi Olsen,Bård Smedsrød,Dmitri Svistounov

Diabetes 59:1386-96 PubMed20299472

2010

Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo.

Applications

ICC/IF

Species

Mouse

Yunzhou Dong,Miao Zhang,Shuangxi Wang,Bin Liang,Zhengxing Zhao,Chao Liu,Mingyuan Wu,Hyoung Chul Choi,Timothy J Lyons,Ming-Hui Zou

Investigative ophthalmology & visual science 49:2679-85 PubMed18362112

2008

Intraretinal leakage and oxidation of LDL in diabetic retinopathy.

Applications

IHC-P

Species

Human

Mingyuan Wu,Ying Chen,Kenneth Wilson,Alin Chirindel,Michael A Ihnat,Yongxin Yu,Michael E Boulton,Luke I Szweda,Jian-Xing Ma,Timothy J Lyons

Cardiovascular research 43:492-9 PubMed10536679

1999

The isoprostane, 8-epi-PGF2 alpha, is accumulated in coronary arteries isolated from patients with coronary heart disease.

Applications

Unspecified application

Species

Unspecified reactive species

M R Mehrabi,C Ekmekcioglu,F Tatzber,A Oguogho,R Ullrich,A Morgan,F Tamaddon,M Grimm,H D Glogar,H Sinzinger

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-LDL (Copper oxidized) antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Reactivity data

Properties and storage information

Form

Purity

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (11)

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise