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AB89835

Anti-LECT2 antibody [MM0449-4B24]

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(2 Publications)

Mouse Monoclonal LECT2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Leukocyte cell-derived chemotaxin-2.

View Alternative Names

Leukocyte cell-derived chemotaxin-2, LECT-2, hLECT2, LECT2

1 Images
Western blot - Anti-LECT2 antibody [MM0449-4B24] (AB89835)
  • WB

Supplier Data

Western blot - Anti-LECT2 antibody [MM0449-4B24] (AB89835)

All lanes:

Western blot - Anti-LECT2 antibody [MM0449-4B24] (ab89835)

Predicted band size: 16 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0449-4B24

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Leukocyte cell-derived chemotaxin-2.

O14960

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Alternative Products

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and sterile filtered through a 0.2 µm filter.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target 'LECT2' also known as leukocyte cell-derived chemotaxin 2 is a 16 kDa protein. It plays a role in immune response and signaling by acting as a chemotactic factor for neutrophils. LECT2 is a secreted protein primarily expressed in the liver and found in circulation in the bloodstream. It has been associated with acute-phase response and inflammation.
Biological function summary

LECT2 contributes to tissue regeneration liver function and modulation of immune responses. It is not known to be part of a larger protein complex but interacts with multiple receptor types on cell surfaces. LECT2 can inhibit mitogen-activated protein kinase (MAPK) pathway by binding to specific receptors affecting cell proliferation and survival. It also plays a role in metabolic processes.

Pathways

The LECT2 protein influences the MAPK and JNK pathways impacting cellular stress responses and inflammatory signaling. Its interactions with other proteins involve MAPK family members like p38 and ERK. These pathways regulate various cellular activities such as proliferation apoptosis and cytokine production positioning LECT2 as a modulator of cellular signaling networks.

LECT2 has strong connections to liver-related conditions such as fatty liver disease and liver fibrosis. It also associates with conditions like amyloid A kidney amyloidosis. In these diseases LECT2 interacts with inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) which play roles in inflammation and fibrosis. These interactions can alter disease outcomes and affect therapeutic strategies targeting these inflammatory pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed : 9524238). Does not show metalloendopeptidase activity (PubMed : 27334921).
See full target information Leukocyte cell-derived chemotaxin-2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Biomedical reports 6:167-174 PubMed28357068

2017

Differential proteomics analysis of liver failure in peripheral blood mononuclear cells using isobaric tags for relative and absolute quantitation.

Applications

Unspecified application

Species

Unspecified reactive species

Hua Lin,Qiu-Pei Tan,Wei-Guo Sui,Wen-Biao Chen,Wu-Jian Peng,Xing-Chao Liu,Yong Dai

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 18:565-72 PubMed23937207

2013

iTRAQ-based proteomics reveals novel biomarkers of osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Daiki Ikeda,Hiroshi Ageta,Kunihiro Tsuchida,Harumoto Yamada
View all publications
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Product promise

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