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AB119429

Anti-LECT2 antibody [OTI2A11]

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(4 Publications)

Mouse Monoclonal LECT2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Leukocyte cell-derived chemotaxin-2.

View Alternative Names

Leukocyte cell-derived chemotaxin-2, LECT-2, hLECT2, LECT2

7 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)

Paraffin-embedded human ovary adenocarcinoma tissue stained for LECT2 using ab119429 at 1/150 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)

Paraffin-embedded human breast tissue stained for LECT2 using ab119429 at 1/150 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)

Paraffin-embedded human lung carcinoma tissue stained for LECT2 using ab119429 at 1/150 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)

Paraffin-embedded human kidney tissue stained for LECT2 using ab119429 at 1/150 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)

Paraffin-embedded human tonsil tissue stained for LECT2 using ab119429 at 1/150 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)

Paraffin-embedded human pancreas tissue stained for LECT2 using ab119429 at 1/150 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LECT2 antibody [OTI2A11] (AB119429)

Paraffin-embedded human endometrium adenocarcinoma tissue stained for LECT2 using ab119429 at 1/150 dilution in immunohistochemical analysis.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI2A11

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Leukocyte cell-derived chemotaxin-2.

O14960

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }
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Product details

The clone number has been updated from 2A11 to OTI2A11, both clone numbers name the same clone.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
Purified from cell culture supernatant by affinity chromatography
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target 'LECT2' also known as leukocyte cell-derived chemotaxin 2 is a 16 kDa protein. It plays a role in immune response and signaling by acting as a chemotactic factor for neutrophils. LECT2 is a secreted protein primarily expressed in the liver and found in circulation in the bloodstream. It has been associated with acute-phase response and inflammation.
Biological function summary

LECT2 contributes to tissue regeneration liver function and modulation of immune responses. It is not known to be part of a larger protein complex but interacts with multiple receptor types on cell surfaces. LECT2 can inhibit mitogen-activated protein kinase (MAPK) pathway by binding to specific receptors affecting cell proliferation and survival. It also plays a role in metabolic processes.

Pathways

The LECT2 protein influences the MAPK and JNK pathways impacting cellular stress responses and inflammatory signaling. Its interactions with other proteins involve MAPK family members like p38 and ERK. These pathways regulate various cellular activities such as proliferation apoptosis and cytokine production positioning LECT2 as a modulator of cellular signaling networks.

LECT2 has strong connections to liver-related conditions such as fatty liver disease and liver fibrosis. It also associates with conditions like amyloid A kidney amyloidosis. In these diseases LECT2 interacts with inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) which play roles in inflammation and fibrosis. These interactions can alter disease outcomes and affect therapeutic strategies targeting these inflammatory pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed : 9524238). Does not show metalloendopeptidase activity (PubMed : 27334921).
See full target information Leukocyte cell-derived chemotaxin-2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Hereditas 162:87 PubMed40413527

2025

BHLHE40-mediated RGS16 upregulation: a driver propelling gastric cancer progression via ferroptosis suppression.

Applications

Unspecified application

Species

Unspecified reactive species

Caiyun Guo,Hua Tang,Maifang Ren,Yongli Zhang

Cell death & disease 13:900 PubMed36289198

2022

TAB182 aggravates progression of esophageal squamous cell carcinoma by enhancing β-catenin nuclear translocation through FHL2 dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Aidi Gao,Zhenzi Su,Zengfu Shang,Chao He,Dongliu Miao,Xiaoqing Li,Shitao Zou,Weiqun Ding,Yue Zhou,Ming Sun,Jundong Zhou

Nature communications 13:3176 PubMed35676290

2022

Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET.

Applications

Unspecified application

Species

Unspecified reactive species

Takayoshi Shirasaki,Satoshi Yamagoe,Tetsuro Shimakami,Kazuhisa Murai,Ryu Imamura,Kiyo-Aki Ishii,Hiroaki Takayama,Yukako Matsumoto,Natsumi Tajima-Shirasaki,Naoto Nagata,Ryogo Shimizu,Souma Yamanaka,Atsushi Abe,Hitoshi Omura,Kazunori Kawaguchi,Hikari Okada,Taro Yamashita,Tomoki Yoshikawa,Kazuhiro Takimoto,Motoko Taharaguchi,Shogo Takatsuka,Yoshitsugu Miyazaki,Toshikatsu Tamai,Yamato Tanabe,Makoto Kurachi,Yasuhiko Yamamoto,Shuichi Kaneko,Kunio Matsumoto,Toshinari Takamura,Masao Honda

Cell 178:1478-1492.e20 PubMed31474362

2019

LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Meng Xu,Hong-Hai Xu,Yuan Lin,Xiangnan Sun,Li-Jing Wang,Zhe-Ping Fang,Xue-Han Su,Xiang-Jing Liang,Yang Hu,Zhi-Min Liu,Yuanxiong Cheng,Yuanyuan Wei,Jiabin Li,Li Li,Hong-Juan Liu,Zhiqiang Cheng,Na Tang,Chao Peng,Tingting Li,Tengfei Liu,Liang Qiao,Dalei Wu,Yan-Qing Ding,Wei-Jie Zhou
View all publications
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Product promise

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