Anti-Legionella pneumophila antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Legionella pneumophila manipulates cellular processes to create a favorable niche for its replication. It forms a specialized compartment known as the Legionella-containing vacuole (LCV) within host cells. The bacterium achieves this by modulating host vesicle trafficking pathways avoiding lysosomal degradation. The LCV selectively recruits endoplasmic reticulum-derived vesicles helping Legionella establish a niche distinct from those normally used by other intracellular pathogens. This process promotes bacterial survival and replication within the host cell cytoplasm.

Pathways

Legionella pneumophila is integrally involved with host autophagy and apoptosis pathways. It possesses proteins that intervene in these cellular pathways to suppress apoptosis of infected cells prolonging its survival. It also hijacks the host's secretory pathway to modulate the transport and secretion of cellular components effectively manipulating host cell functions. The manipulation of pathways involves interactions with host proteins such as Rab1 which is important for its replication and survival.