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AB201206

Anti-LEMD1 antibody

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(5 Publications)

Rabbit Polyclonal LEMD1 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LEMD1 aa 1 to C-terminus.

View Alternative Names

LEM domain-containing protein 1, Cancer/testis antigen 50, LEM domain protein 1, CT50, LEMP-1, LEMD1

1 Images
Western blot - Anti-LEMD1 antibody (AB201206)
  • WB

Supplier Data

Western blot - Anti-LEMD1 antibody (AB201206)

All lanes:

Western blot - Anti-LEMD1 antibody (ab201206) at 1/1000 dilution

All lanes:

Human fetal testis lysate

Predicted band size: 20 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human LEMD1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q68G75

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
reconstitute with water at 200µL
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.01% Sodium azide Constituents: 98% PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LEMD1 also known as LEM domain containing protein 1 is a protein associated with the inner nuclear membrane. The protein weighs approximately 43 kDa. It expresses predominantly in testicular tissue and some cancers. LEMD1 contains the LEM domain known for its involvement in chromatin organization and nuclear structure interactions and plays a mechanical role in maintaining nuclear integrity and possibly gene regulation.
Biological function summary

LEMD1 participates in nuclear architecture through its role in forming the inner nuclear membrane structure. It is a component of the nuclear lamina a fibrous network inside the nucleus that provides structural support. LEMD1 interacts with other nuclear membrane proteins and chromatin suggesting its involvement in maintaining chromatin stability and epigenetic regulation. Its function in nuclear dynamics indicates an important role in cellular processes like cell division and differentiation.

Pathways

LEMD1 integrates into mechanisms involving nuclear envelope dynamics and chromatin remodeling. It plays a role in the cellular process pathway specifically linked to the regulation of nuclear assembly and disassembly. LEMD1 associates with proteins such as emerin and LAP2 which are also integral to nuclear membrane functions. It supports the proper execution of key biological processes including gene expression and DNA replication by maintaining nuclear structural integrity.

LEMD1 shows relevance in certain cancers such as prostate cancer. Alterations in LEMD1 expression associate with tumorigenic processes indicating its potential role as a biomarker for cancer progression. In cancer its connection to nuclear structure disruptions relates it to proteins like lamin A/C and emerin which also play roles in nuclear stability and have implications in oncogenic transformations. These associations highlight the potential impact of nuclear envelope components in cancer biology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information LEMD1
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cancers 15: PubMed37296887

2023

LEM Domain Containing 1 Acts as a Novel Oncogene and Therapeutic Target for Triple-Negative Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangling Li,Shilong Jiang,Ting Jiang,Xinyuan Sun,Yidi Guan,Songqing Fan,Yan Cheng

Frontiers in oncology 12:823696 PubMed35619906

2022

A Three-Genes Signature Predicting Colorectal Cancer Relapse Reveals LEMD1 Promoting CRC Cells Migration by RhoA/ROCK1 Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Zhang,Chenxin Xu,Feng Jiang,Jifeng Feng

Bioengineered 13:7771-7784 PubMed35286235

2022

LEM domain containing 1 promotes pancreatic cancer growth and metastasis by p53 and mTORC1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiang Cao,Na Yao,Zidan Zhao,Yue Fu,Yuting Hu,Ping Zhu,Weihai Shi,Liming Tang

Oncology letters 21:442 PubMed33868480

2021

LEM domain containing 1 promotes thyroid cancer cell proliferation and migration by activating the Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition.

Applications

Unspecified application

Species

Unspecified reactive species

Min Xu,Bangyi Lin,Danni Zheng,Jialiang Wen,Wenjing Hu,Chunxue Li,Xianwei Zhang,Xiaohua Zhang,Jinmiao Qu

Journal of cellular biochemistry 120:15190-15201 PubMed31021450

2019

LEM domain containing 1 promotes proliferation via activating the PI3K/Akt signaling pathway in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Qiang Li,Yugang Ge,Xiaofeng Chen,Lu Wang,Yiwen Xia,Zhipeng Xu,Zheng Li,Weizhi Wang,Li Yang,Diancai Zhang,Zekuan Xu
View all publications
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