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AB230864

Anti-LENG8 antibody

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(1 Publication)

Rabbit Polyclonal LENG8 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LENG8 aa 450-700.

View Alternative Names

KIAA1932, LENG8, Leukocyte receptor cluster member 8

3 Images
Western blot - Anti-LENG8 antibody (AB230864)
  • WB

Supplier Data

Western blot - Anti-LENG8 antibody (AB230864)

All lanes:

Western blot - Anti-LENG8 antibody (ab230864) at 1/1000 dilution

Lane 1:

Human fetal heart lysate

Lane 2:

Human kidney lysate

Predicted band size: 86 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LENG8 antibody (AB230864)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LENG8 antibody (AB230864)

Formalin-fixed, paraffin-embedded human prostate tissue stained for LENG8 using ab230864 at 5 μg/ml in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LENG8 antibody (AB230864)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LENG8 antibody (AB230864)

Formalin-fixed, paraffin-embedded human thymus tissue stained for LENG8 using ab230864 at 5 μg/ml in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human LENG8 aa 450-700. The exact immunogen used to generate this antibody is proprietary information.

Q96PV6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LENG8 also known as Leukocyte Receptor Cluster Member 8 is a protein that plays an important role in immune signaling. The molecular weight of LENG8 is approximately 25 kDa. LENG8 shows expression mainly in immune-related tissues like the spleen and lymph nodes indicating its role in the immune system. Its expression patterns suggest a functional role in immune cell interaction and signaling.
Biological function summary

The actions of LENG8 are tied to immune cell interaction within the leukocyte receptor cluster. It does not work as an isolated protein but participates as part of a broader protein network. This cluster involves several receptors linked to immune modulation. LENG8 possibly influences the regulation of immune responses contributing to maintaining immune homeostasis.

Pathways

Researchers have connected LENG8 to immune-related signaling pathways such as the cytokine receptor signaling pathway. Its involvement here suggests interactions with various cytokine receptors and other leukocyte receptors. These interactions place LENG8 in the broader context of immune cell activation and communication potentially interacting with proteins such as IL-2 and IL-4 which are key players in controlling immune responses.

LENG8's role in immune regulation implies a potential connection to autoimmune diseases like rheumatoid arthritis. Dysfunction or altered expression of LENG8 might influence disease progression due to its impact on immune cell signaling. In rheumatoid arthritis proteins such as TNF-alpha and IL-6 which regulate inflammatory responses might exhibit altered interactions with the pathways that involve LENG8 contributing to the disease pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information LENG8
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 134: PubMed38885336

2024

The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect.

Applications

Unspecified application

Species

Unspecified reactive species

Ronit Marom,I-Wen Song,Emily C Busse,Megan E Washington,Ava S Berrier,Vittoria C Rossi,Laura Ortinau,Youngjae Jeong,Ming-Ming Jiang,Brian C Dawson,Mary Adeyeye,Carolina Leynes,Caressa D Lietman,Bridget M Stroup,Dominyka Batkovskyte,Mahim Jain,Yuqing Chen,Racel Cela,Alexis Castellon,Alyssa A Tran,Isabel Lorenzo,D Nicole Meyers,Shixia Huang,Alicia Turner,Vinitha Shenava,Maegen Wallace,Eric Orwoll,Dongsu Park,Catherine G Ambrose,Sandesh Cs Nagamani,Jason D Heaney,Brendan H Lee
View all publications
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Product promise

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