AB233445

Anti-LETMD1/HCCR-1 antibody

Name: Anti-LETMD1/HCCR-1 antibody (ab233445) | Abcam
Brand: Abcam Limited
SKU: AB233445
Price: 525 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal LETMD1/HCCR-1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Cow samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LETM1 domain-containing protein 1 aa 150-350.

View Alternative Names

LETM1 domain-containing protein 1, Cervical cancer 1 proto-oncogene protein p40, Cervical cancer proto-oncogene 2 protein, HCCR-1, HCRR-2, LETMD1

8 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LETMD1/HCCR-1 antibody (AB233445)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LETMD1/HCCR-1 antibody (AB233445)

Formalin-fixed, paraffin-embedded human stomach cancer tissue stained for LETMD1/HCCR-1 using ab233445 at 20μg/mL in immunohistochemical analysis. DAB staining.

Immunocytochemistry/ Immunofluorescence - Anti-LETMD1/HCCR-1 antibody (AB233445)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-LETMD1/HCCR-1 antibody (AB233445)

Immunocytochemistry/ Immunofluorescence of HeLa cells staining LETMD1/HCCR-1 using ab233445 5 μg/mL

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LETMD1/HCCR-1 antibody (AB233445)

Formalin-fixed, paraffin-embedded human stomach tissue stained for LETMD1/HCCR-1 using ab233445 at 20μg/mL in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LETMD1/HCCR-1 antibody (AB233445)

Formalin-fixed, paraffin-embedded human prostate tissue stained for LETMD1/HCCR-1 using ab233445 at 20μg/mL in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LETMD1/HCCR-1 antibody (AB233445)

Formalin-fixed, paraffin-embedded human kidney tissue stained for LETMD1/HCCR-1 using ab233445 at 20μg/mL in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-LETMD1/HCCR-1 antibody (AB233445)

All lanes:

Western blot - Anti-LETMD1/HCCR-1 antibody (ab233445) at 2 µg/mL

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HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate.

Predicted band size: 42 kDa

false

Supplier Data

Western blot - Anti-LETMD1/HCCR-1 antibody (AB233445)

All lanes:

Western blot - Anti-LETMD1/HCCR-1 antibody (ab233445) at 2 µg/mL

All lanes:

Recombinant human LETMD1/HCCR-1 protein

Predicted band size: 42 kDa

false

Supplier Data

Western blot - Anti-LETMD1/HCCR-1 antibody (AB233445)

All lanes:

Western blot - Anti-LETMD1/HCCR-1 antibody (ab233445) at 2 µg/mL

All lanes:

Cow kidney tissue lysate

Predicted band size: 42 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Cow, Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human LETM1 domain-containing protein 1 aa 150-350. The exact immunogen used to generate this antibody is proprietary information.

Q6P1Q0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "5-20 µg/mL", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LETMD1 also known as HCCR-1 functions mechanically as a mitochondrial protein that plays a role in regulating mitochondrial activity and cellular apoptosis. With a mass of approximately 60 kDa LETMD1/HCCR-1 is expressed in various tissues including the liver kidney and lung. This protein has been identified to participate in the mitochondrial pathways and contribute to cellular homeostasis and energy metabolism.

Biological function summary

LETMD1/HCCR-1 affects cellular processes like cell growth and death by impacting the mitochondrial function critical to these processes. Although not specifically a component of a known complex this protein influences important cellular dynamics. Its role in the regulation of apoptosis links LETMD1/HCCR-1 to cellular survival implying its importance in balancing cell proliferation and death under physiological conditions.

Pathways

LETMD1/HCCR-1 is associated closely with apoptosis and mitochondrial pathways. The protein regulates apoptosis interacting with members of the Bcl-2 family of proteins which are important in apoptosis regulation. LETMD1/HCCR-1's connection to mitochondrial dynamics also overlaps with pathways involving mitochondrial fusion and fission highlighting its integrative role in maintaining cellular energy balance and function.

LETMD1/HCCR-1 links to cancer and neurodegenerative disorders. Overexpression of LETMD1/HCCR-1 has been noted in various cancers where it may promote tumor cell survival through inhibition of apoptosis. Neurodegenerative diseases such as Alzheimer's disease also show LETMD1/HCCR-1 involvement possibly through its interaction with proteins like p53 which is significant in cell cycle regulation and apoptosis. Understanding LETMD1/HCCR-1's interaction with these proteins aids in exploring therapeutic targets for these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (By similarity). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (PubMed : 31980577). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (PubMed : 12879013).

See full target information LETM1 domain-containing protein 1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:7827 PubMed40846845

2025

Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hanshen Yang,Xiaozhen Zhang,Sirui Zhang,Yanqing Yang,Yan Chen,Yangwei Jiang,Qingsong Lu,Lingyue Liu,Mengyi Lao,Weiran Du,Kang Sun,Lihong He,Jiatao Shi,Xinyuan Liu,Jinyuan Song,Na Lu,Junming Huang,Jinyan Huang,Ruhong Zhou,Xiongbin Lu,Tingbo Liang,Xueli Bai

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-LETMD1/HCCR-1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LETMD1/HCCR-1 antibody (AB233445)

Immunocytochemistry/ Immunofluorescence - Anti-LETMD1/HCCR-1 antibody (AB233445)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LETMD1/HCCR-1 antibody (AB233445)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LETMD1/HCCR-1 antibody (AB233445)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LETMD1/HCCR-1 antibody (AB233445)

Western blot - Anti-LETMD1/HCCR-1 antibody (AB233445)

Western blot - Anti-LETMD1/HCCR-1 antibody (AB233445)

Western blot - Anti-LETMD1/HCCR-1 antibody (AB233445)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise