AB150346

Anti-Leu Enkephalin antibody [NOC1]

Name: Anti-Leu Enkephalin antibody [NOC1] (ab150346) | Abcam
Brand: Abcam Limited
SKU: AB150346
Price: 490 USD
Availability: InStock
Rating: 5 (3 reviews)

(3 Reviews)

(10 Publications)

Mouse Monoclonal Enkephalin antibody. Suitable for ICC, IHC-P, RIA, IHC-Fr and reacts with Mouse, Rat, Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human PENK conjugated to Bovine Serum Albumin.

View Alternative Names

Proenkephalin-A, PENK

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

NOC1

Isotype

IgG1

Carrier free

Reacts with

Rat, Human, Mouse

Applications

IHC-Fr, ICC, IHC-P, RIA

applications

Immunogen

Synthetic Peptide within Human PENK conjugated to Bovine Serum Albumin. The exact immunogen used to generate this antibody is proprietary information.

P01210

Specificity

This antibody does not distinguish between Met-enkephalin and Leu-enkephalin by radioimmunoassay or by immunocytochemistry.

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Reactivity data

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Purification notes

ab150346 is in a protein-free culture medium.

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Leu-enkephalin also known as leucine-enkephalin is a pentapeptide with the sequence Tyr-Gly-Gly-Phe-Leu. This enkephalin with a molecular mass of approximately 555.6 Da primarily expresses in the central nervous system where it acts as a neurotransmitter and neuromodulator. It binds to the delta opioid receptors mediating various physiological functions. Leu-enkephalin and its structural variant Met-enkephalin are notable for their role in modulating pain perception and producing analgesic effects.

Biological function summary

Enkephalins are endogenous peptides involved in pain regulation and stress responses. These peptides are important in the body’s ability to cope with stressors and reduce pain signals. Enkephalins including Leu-enkephalin inhibit neurotransmitter release by binding to specific opioid receptors found throughout the nervous system. They are not part of a larger protein complex but are a vital component in neurotransmission processes.

Pathways

Enkephalins play a significant role in the endogenous opioid pathway interacting closely with delta opioid receptors. This interaction affects the brain's reward and pain pathways. The endogenous opioid pathway involves other opioid peptides such as beta-endorphins and dynorphins which Leu-enkephalin functions alongside. These pathways are significant in managing emotional states related to reward and pain modulation.

Leu-enkephalin is linked to conditions such as chronic pain and opioid addiction. Dysregulation of enkephalin production or receptor function may contribute to these disorders. The delta opioid receptor which Leu-enkephalin binds is often a target in research seeking to develop safer analgesics by minimizing addiction potential. Understanding these interactions helps in developing therapeutic strategies that may mitigate adverse effects associated with pain management and addiction therapies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Met-enkephalin. Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.. Leu-enkephalin. Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.. Met-enkephalin-Arg-Phe. Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release.. PENK(114-133). Increases glutamate release in the striatum and decreases GABA concentration in the striatum.. PENK(237-258). Increases glutamate release in the striatum.

See full target information PENK

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Nature neuroscience 28:1146-1159 PubMed40442499

2025

The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Li,Khomgrit Morarach,Ziwei Liu,Sanghita Banerjee,Yanan Chen,Ashley L Harb,Joel M Kosareff,Charles R Hall,Fernando López-Redondo,Elham Jalalvand,Suad H Mohamed,Anastassia Mikhailova,David R Linden,Ulrika Marklund

Cellular and molecular gastroenterology and hepatology 13:309-337.e3 PubMed34509687

2021

Unique Neural Circuit Connectivity of Mouse Proximal, Middle, and Distal Colon Defines Regional Colonic Motor Patterns.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea Nestor-Kalinoski,Kristen M Smith-Edwards,Kimberly Meerschaert,Joseph F Margiotta,Bartek Rajwa,Brian M Davis,Marthe J Howard

The Journal of neuroscience : the official journal of the Society for Neuroscience 41:7727-7741 PubMed34349001

2021

G-Protein-Coupled Estrogen Receptor (GPER) in the Rostral Ventromedial Medulla Is Essential for Mobilizing Descending Inhibition of Itch.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Gao,Li Dong,Jiahong Qian,Xiaowei Ding,Yi Zheng,Meimei Wu,Li Meng,Yingfu Jiao,Po Gao,Ping Luo,Guohua Zhang,Changhao Wu,Xueyin Shi,Weifang Rong

Frontiers in genetics 11:551065 PubMed33424913

2020

Integration of Transcriptome Resequencing and Quantitative Proteomics Analyses of Collagenase VII-Induced Intracerebral Hemorrhage in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Cao,Yu Guo,Qiang Zhang,Yinchun Fan,Qian Liu,Jiancheng Song,Hua Zhong,Shengtao Yao

Brain sciences 9: PubMed31752398

2019

Transient Chemogenetic Inhibition of D1-MSNs in the Dorsal Striatum Enhances Methamphetamine Self-Administration.

Applications

Unspecified application

Species

Unspecified reactive species

Robert J Oliver,Dvijen C Purohit,Khush M Kharidia,Chitra D Mandyam

Endocrine regulations 53:165-177 PubMed31517634

2019

Spatial relationship between the c-Fos distribution and enkephalinergic, substance P, and tyrosine hydroxylase innervation fields after acute treatment with neuroleptics olanzapine, amisulpride, quetiapine, and aripiprazole in the rat septum.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander Kiss,Jana Osacka

Cancer management and research 11:6681-6690 PubMed31410059

2019

High expression of proenkephalin is associated with favorable outcomes in patients with gastrointestinal stromal tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Defeng Tang,Tianlong Lin,Yangyang Wang,Hui Cao

Frontiers in cellular neuroscience 12:417 PubMed30555300

2018

TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.

Applications

Unspecified application

Species

Unspecified reactive species

Cong Zheng,Guiqin Chen,Yang Tan,Weiqi Zeng,Qiwei Peng,Ji Wang,Chi Cheng,Xiaoman Yang,Shuke Nie,Yan Xu,Zhentao Zhang,Stella M Papa,Keqiang Ye,Xuebing Cao

Neuropathology and applied neurobiology 42:521-34 PubMed26859760

2016

Protein regulation of induced pluripotent stem cells by transplanting in a Huntington's animal model.

Applications

Unspecified application

Species

Unspecified reactive species

S Mu,L Han,G Zhou,C Mo,J Duan,Z He,Z Wang,L Ren,J Zhang

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 32:947-57 PubMed6086744

1984

Characterization and immunocytochemical application of monoclonal antibodies against enkephalins.

Applications

Unspecified application

Species

Unspecified reactive species

A C Cuello,C Milstein,R Couture,B Wright,J V Priestley,J Jarvis

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Leu Enkephalin antibody [NOC1]

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purity

Purification notes

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (10)

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