Anti-Leukotriene B4 Receptor/BLT antibody [EPR7113] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Leukotriene B4 Receptor often referred to as BLT or BLT1 plays a significant mechanical role in the immune response by binding to leukotriene B4 (LTB4) a potent chemoattractant. This receptor has a molecular mass of about 45 kDa. It expresses primarily on leukocytes including neutrophils macrophages and certain T cells. Furthermore BLT1 can also be observed in other tissues such as the spleen and liver where immune modulation has essential roles.

Biological function summary

The function of BLT1 involves mediating cell migration particularly during inflammatory responses. When LTB4 binds to BLT1 it activates intracellular signaling pathways that lead to chemotaxis and activation of immune cells. This receptor does not function in isolation; it forms part of receptor complexes on the cell surface to facilitate effective signal transduction. Although its name suggests specificity BLT1 can interact with other related lipid mediators amplifying its role in inflammation.

Pathways

Leukotriene B4 receptor BLT1 is integral to the arachidonic acid pathway and the GPCR signaling pathway. In the arachidonic acid pathway BLT1 contributes to the production of inflammatory mediators that recruit immune cells to sites of injury or infection. This receptor shares pathways with other GPCRs facilitating coordinated responses to external stimuli. It is closely related to protein kinase C (PKC) in the pathways which plays a role in signal transduction and cellular communication.

Associated diseases and disorders

Leukotriene B4 receptor BLT1 has significant implications in chronic inflammatory diseases such as asthma and rheumatoid arthritis. Overactivation of BLT1 can result in excessive recruitment of immune cells exacerbating inflammation and tissue damage in these conditions. The receptor is also connected to COX-2 which is involved in the inflammation process linking BLT1 to the broader picture of inflammatory pathways in disease states. Understanding BLT1's role in these diseases helps identify potential therapeutic targets for managing inflammation-related pathologies.