Anti-LexA DNA Binding Region antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The LexA DNA binding region is a component of the LexA protein also referred to simply as 'LexA'. LexA functions as a repressor protein in bacterial cells and has a molecular mass typically around 22.5 kDa. It is expressed in various bacterial species where it plays an important role in regulating DNA repair processes. LexA achieves its function by binding to specific DNA sequences and blocking transcription of genes involved in the SOS response.

Biological function summary

The LexA protein is critical in maintaining genomic integrity by controlling the expression of DNA repair genes. It is not usually part of a larger protein complex but operates independently within cells. In its inactive form LexA binds to the promoter regions of genes associated with the SOS response preventing their transcription. In response to DNA damage the RecA protein facilitates LexA's self-cleavage allowing for the induction of DNA repair genes.

Pathways

LexA is involved in the bacterial SOS response and DNA damage repair pathways. These pathways are vital for the organism's survival during genotoxic stress by coordinating the repair of damaged DNA. LexA works alongside other proteins such as RecA which senses DNA damage and aids in the self-cleavage of LexA releasing the suppression on SOS genes therefore initiating the repair process.

Associated diseases and disorders

LexA's role is critical in bacterial resistance to antibiotics. The SOS response controlled by LexA can lead to increased mutation rates following antibiotic exposure potentially resulting in the development of antibiotic resistance. Understanding LexA's interactions with other proteins like RecA and its role in these processes could offer insights into more effective treatments to combat bacterial infections and reduce antibiotic resistance.