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AB235039

Anti-LGALS12 antibody

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(1 Publication)

Rabbit Polyclonal LEG12 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LGALS12.

View Alternative Names

GRIP1, LGALS12, Galectin-12, Gal-12, Galectin-related inhibitor of proliferation

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS12 antibody (AB235039)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS12 antibody (AB235039)

Paraffin-embedded human breast cancer tissue stained for LGALS12 using ab235039 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS12 antibody (AB235039)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS12 antibody (AB235039)

Paraffin-embedded human skin tissue stained for LGALS12 using ab235039 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-LGALS12 antibody (AB235039)
  • WB

Supplier Data

Western blot - Anti-LGALS12 antibody (AB235039)

All lanes:

Western blot - Anti-LGALS12 antibody (ab235039) at 1/500 dilution

Lane 1:

A549 (human lung carcinoma cell line) whole cell lysate

Lane 2:

Rat kidney lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 38 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human LGALS12.

Q96DT0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/500", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LGALS12 also known as Galectin-12 is a protein involved in various cellular processes. This protein has a molecular mass of approximately 33 kDa and belongs to the galectin family which is known for its role in binding beta-galactosides. LGALS12 expresses largely in adipose tissues leucocytes and testis with some presence in the organs related to the immune system. Its carbohydrate-recognition domain plays an important role in mediating cell-cell and cell-matrix interactions affecting activities like cell adhesion and signaling.
Biological function summary

LGALS12 influences processes through its cellular functions beyond carbohydrate binding. It is implicated in the regulation of cell growth apoptosis and immune responses. LGALS12 itself does not form a complex but modulates the activities of proteins by affecting signal transduction pathways and cellular networks. These functions suggest its involvement in energy homeostasis and immune response regulation contributing to overall organismal physiology.

Pathways

LGALS12 participates significantly in the insulin signaling pathway and adipogenesis. It affects the insulin signaling by modulating insulin sensitivity and glucose uptake interacting with proteins like insulin receptor substrate (IRS). In adipogenesis LGALS12 influences the differentiation of preadipocytes into adipocytes related to PPARγ a nuclear receptor playing an important role in fat cell formation. These pathways highlight its function in metabolic regulation and energy balance.

LGALS12 associations appear in relation to obesity and certain metabolic syndromes. Altered expression or dysregulation of LGALS12 can influence adipocyte functioning potentially leading to obesity. In addition links to type 2 diabetes emerge due to its role in insulin responsiveness implicating proteins such as AKT which mediate insulin effects on glucose metabolism. Research continues to explore these connections aiming to establish LGALS12 as a target for therapeutic interventions in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds lactose. May participate in the apoptosis of adipocytes.
See full target information LGALS12
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Redox biology 24:101211 PubMed31108460

2019

Ferroptosis is governed by differential regulation of transcription in liver cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Zhang,Lutao Du,Yongxia Qiao,Xiaobai Zhang,Weisheng Zheng,Qi Wu,Yan Chen,Guoqing Zhu,Ya Liu,Zhixuan Bian,Susu Guo,Yueyue Yang,Lifang Ma,Yongchun Yu,Qiuhui Pan,Fenyong Sun,Jiayi Wang
View all publications
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