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AB217760

Anti-LGALS3BP antibody

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(4 Publications)

Rabbit Polyclonal LGALS3BP antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human LGALS3BP aa 300-400 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

M2BP, LGALS3BP, Galectin-3-binding protein, Basement membrane autoantigen p105, Lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, Tumor-associated antigen 90K, MAC2BP, Mac-2 BP

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS3BP antibody (AB217760)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LGALS3BP antibody (AB217760)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon carcinoma tissue labeling LGALS3BP

with ab217760 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Western blot - Anti-LGALS3BP antibody (AB217760)
  • WB

Supplier Data

Western blot - Anti-LGALS3BP antibody (AB217760)

12% gel.

All lanes:

Western blot - Anti-LGALS3BP antibody (ab217760) at 1/200 dilution

All lanes:

Mouse serum lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP at 1/3000 dilution

Predicted band size: 65 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human LGALS3BP aa 300-400 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q08380

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Alternative Products

Primary Antibodies

AB67353

Anti-LGALS3BP antibody

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

AB217572

Anti-LGALS3BP antibody [EPR21757-33]

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Complementary Products

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Secondary Antibodies

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Primary Antibodies

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Primary Antibodies

AB15580

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LGALS3BP also known as Galectin-3-binding protein (Mac-2 binding protein 90K) is a multifaceted glycoprotein with a mass of approximately 90 kDa. It typically interacts with galectins especially galectin-3 and is known for its adhesive properties. Researchers frequently observe it in various tissues including epithelial cells immune cells and in the extracellular matrix highlighting its involvement across different biological functions.
Biological function summary

The LGALS3BP glycoprotein modulates cell-cell and cell-matrix interactions. It does not operate alone; researchers have identified its presence in multiple complexes impacting several cellular processes such as immune modulation cell adhesion and migration. LGALS3BP can affect the immune response by influencing T-cell and natural killer cell activities which can alter the body's defense against pathogens and tumors.

Pathways

LGALS3BP significantly influences the signaling pathways involved with immune function and cellular adhesion. It plays an important role in the galectin pathway where it interacts with galectin-3 contributing to processes like cell growth and apoptosis. Additionally it affects the integrin-mediated signaling pathway enhancing cell adhesion and motility which is vital for cell migration and signaling dynamics. These interactions involve proteins such as integrins and other adhesion molecules that influence cellular communication and structural integrity.

LGALS3BP is strongly linked to cancer and inflammation-related conditions. Its overexpression is correlated with tumor progression and metastasis as seen in various cancers such as breast and colorectal cancer. LGALS3BP modulates its effects by interacting with galectin-3 influencing tumor-immune escape mechanisms and promoting tumor growth. Further its role in inflammatory disorders suggests it contributes to pathological processes through interactions with proteins that mediate inflammation and immune response.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
See full target information LGALS3BP
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cell reports. Medicine 5:101505 PubMed38614095

2024

Macrophage-coated tumor cluster aggravates hepatoma invasion and immunotherapy resistance via generating local immune deprivation.

Applications

Unspecified application

Species

Unspecified reactive species

Junya Ning,Yingnan Ye,Hongru Shen,Runjiao Zhang,Huikai Li,Tianqiang Song,Rui Zhang,Pengpeng Liu,Guidong Chen,Hailong Wang,Fenglin Zang,Xiangchun Li,Jinpu Yu

Regenerative therapy 20:165-186 PubMed35620640

2022

Critical roles of FGF, RA, and WNT signalling in the development of the human otic placode and subsequent lineages in a dish.

Applications

Unspecified application

Species

Unspecified reactive species

Tsubasa Saeki,Sho Yoshimatsu,Mitsuru Ishikawa,Chung-Chau Hon,Ikuko Koya,Shinsuke Shibata,Makoto Hosoya,Chika Saegusa,Kaoru Ogawa,Jay W Shin,Masato Fujioka,Hideyuki Okano

eLife 11: PubMed35543624

2022

Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme.

Applications

Unspecified application

Species

Unspecified reactive species

Guillaume Jacquemin,Annabelle Wurmser,Mathilde Huyghe,Wenjie Sun,Zeinab Homayed,Candice Merle,Meghan Perkins,Fairouz Qasrawi,Sophie Richon,Florent Dingli,Guillaume Arras,Damarys Loew,Danijela Vignjevic,Julie Pannequin,Silvia Fre

Frontiers in cell and developmental biology 9:697539 PubMed34262908

2021

Punicalagin Attenuates Disturbed Flow-Induced Vascular Dysfunction by Inhibiting Force-Specific Activation of Smad1/5.

Applications

Unspecified application

Species

Unspecified reactive species

Gulinigaer Anwaier,Guan Lian,Gui-Zhi Ma,Wan-Li Shen,Chih-I Lee,Pei-Ling Lee,Zhan-Ying Chang,Yun-Xia Wang,Xiao-Yu Tian,Xiao-Li Gao,Jeng-Jiann Chiu,Rong Qi
View all publications
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Product promise

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