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AB67353

Anti-LGALS3BP antibody

3

(2 Reviews)

|

(6 Publications)

Mouse Polyclonal LGALS3BP antibody. Carrier free. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LGALS3BP.

View Alternative Names

M2BP, LGALS3BP, Galectin-3-binding protein, Basement membrane autoantigen p105, Lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, Tumor-associated antigen 90K, MAC2BP, Mac-2 BP

1 Images
Western blot - Anti-LGALS3BP antibody (AB67353)
  • WB

Unknown

Western blot - Anti-LGALS3BP antibody (AB67353)

All lanes:

Western blot - Anti-LGALS3BP antibody (ab67353) at 1/500 dilution

Lane 1:

LGALS3BP transfected 293T cell lysate at 25 µg

Lane 2:

Non transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 65 kDa

Observed band size: 80 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human LGALS3BP.

Q08380

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LGALS3BP also known as Galectin-3-binding protein (Mac-2 binding protein 90K) is a multifaceted glycoprotein with a mass of approximately 90 kDa. It typically interacts with galectins especially galectin-3 and is known for its adhesive properties. Researchers frequently observe it in various tissues including epithelial cells immune cells and in the extracellular matrix highlighting its involvement across different biological functions.
Biological function summary

The LGALS3BP glycoprotein modulates cell-cell and cell-matrix interactions. It does not operate alone; researchers have identified its presence in multiple complexes impacting several cellular processes such as immune modulation cell adhesion and migration. LGALS3BP can affect the immune response by influencing T-cell and natural killer cell activities which can alter the body's defense against pathogens and tumors.

Pathways

LGALS3BP significantly influences the signaling pathways involved with immune function and cellular adhesion. It plays an important role in the galectin pathway where it interacts with galectin-3 contributing to processes like cell growth and apoptosis. Additionally it affects the integrin-mediated signaling pathway enhancing cell adhesion and motility which is vital for cell migration and signaling dynamics. These interactions involve proteins such as integrins and other adhesion molecules that influence cellular communication and structural integrity.

LGALS3BP is strongly linked to cancer and inflammation-related conditions. Its overexpression is correlated with tumor progression and metastasis as seen in various cancers such as breast and colorectal cancer. LGALS3BP modulates its effects by interacting with galectin-3 influencing tumor-immune escape mechanisms and promoting tumor growth. Further its role in inflammatory disorders suggests it contributes to pathological processes through interactions with proteins that mediate inflammation and immune response.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
See full target information LGALS3BP
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Hepatology research : the official journal of the Japan Society of Hepatology : PubMed39257093

2024

Hepatic Mac2-BP expression depends on liver fibrosis and inflammation due to fat accumulation in patients with metabolic dysfunction-associated steatotic liver disease.

Applications

Unspecified application

Species

Unspecified reactive species

Haruki Uojima,Hanako Tsujikawa,Ken Yamazaki,Masaya Sugiyama,Akira Take,Yoshihiko Sakaguchi,Kazuyoshi Gotoh,Takashi Satoh,Hisashi Hidaka,Shunji Hayashi,Chika Kusano,Michiie Sakamoto,Masashi Mizokami

Journal of proteomics 232:104069 PubMed33309826

2020

Proteomic analysis of extracellular vesicles and conditioned medium from human adipose-derived stem/stromal cells and dermal fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Stefania Niada,Chiara Giannasi,Cinzia Magagnotti,Annapaola Andolfo,Anna Teresa Brini

The Journal of infectious diseases 219:867-876 PubMed30312441

2018

Proteomic Profile Associated With Loss of Spontaneous Human Immunodeficiency Virus Type 1 Elite Control.

Applications

Unspecified application

Species

Unspecified reactive species

Esther Rodríguez-Gallego,Laura Tarancón-Diez,Felipe García,Jorge Del Romero,Jose Miguel Benito,Verónica Alba,Pol Herrero,Anna Rull,Beatriz Dominguez-Molina,Onofre Martinez-Madrid,Luisa Martin-Pena,Federico Pulido,Agathe León,Carmen Rodríguez,Norma Rallón,Joaquim Peraire,Consuelo Viladés,Manuel Leal,Francesc Vidal,Ezequiel Ruiz-Mateos

Hepatology communications 1:780-791 PubMed29404494

2017

Use of Mac-2 binding protein as a biomarker for nonalcoholic fatty liver disease diagnosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshihiro Kamada,Masafumi Ono,Hideyuki Hyogo,Hideki Fujii,Yoshio Sumida,Makoto Yamada,Kojiroh Mori,Saiyu Tanaka,Tomohiro Maekawa,Yusuke Ebisutani,Akiko Yamamoto,Shinji Takamatsu,Masashi Yoneda,Norifumi Kawada,Kazuaki Chayama,Toshiji Saibara,Tetsuo Takehara,Eiji Miyoshi

Respiratory medicine 115:46-52 PubMed27215503

2016

Increased levels of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in idiopathic pulmonary fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Masato Kono,Yutaro Nakamura,Yoshiyuki Oyama,Kazutaka Mori,Hironao Hozumi,Masato Karayama,Dai Hashimoto,Noriyuki Enomoto,Tomoyuki Fujisawa,Naoki Inui,Masaomi Yamada,Etsuko Hamada,Thomas V Colby,Masato Maekawa,Takafumi Suda

Proteomics 11:4677-87 PubMed22113853

2011

Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics.

Applications

WB

Species

Human

Yuan Tian,Zhihao Yao,Richard B S Roden,Hui Zhang
View all publications
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