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AB112893

Anti-LGB antibody

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(10 Publications)

Rabbit Polyclonal LGB antibody. Suitable for WB, ICC/IF, ELISA and reacts with Cow samples. Cited in 10 publications. Immunogen corresponding to Full Length Protein corresponding to Cow LGB.

View Alternative Names

Beta-lactoglobulin, Beta-LG, LGB

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Cow

Applications

WB, ICC/IF, ELISA

applications

Immunogen

Full Length Protein corresponding to Cow LGB. The exact immunogen used to generate this antibody is proprietary information.

P02754

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Secondary Antibodies

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Primary Antibodies

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Anti-Mucin 5AC antibody [45M1]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Cow": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/1000 - 1/30000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/200 - 1/2000", "ICCIF-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antiserum was solid phase adsorbed to ensure specificity. ab112893 was isolated by affinity chromatography using antigen coupled to agarose beads.
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LGB also known as beta-lactoglobulin is a small globular protein with a mass of approximately 18 kDa. It is predominantly expressed in the milk of ruminants including cows sheep and goats. The protein is considered a major whey protein and it forms small soluble aggregates in milk. LGB exhibits the ability to bind hydrophobic molecules which suggests it plays a role in transport or storage of lipophilic molecules within milk.
Biological function summary

This protein functions in the stabilization and transport of fatty acids and other hydrophobic molecules. LGB does not form part of a larger protein complex but can dimerize under certain conditions. It has a notable affinity for binding ligands particularly vitamins and flavor compounds which may significantly influence nutritional and sensory qualities of milk and dairy products.

Pathways

LGB's functional role suggests involvement in metabolic and nutritional pathways related to lipid transport and digestion. It has an indirect relationship with the digestive enzyme lipase as LGB-bound lipids become more accessible for digestion. Furthermore its lipid-binding characteristics support its involvement with fatty acid metabolism playing a role similar to serum albumin in circulating lipid constituents.

LGB is most commonly implicated in food allergies particularly cow's milk allergy. Its antigenic properties make it a significant allergen in humans especially young children. Through this context LGB relates to the immune response proteins such as immunoglobulin E (IgE) which mediate allergic reactions. Understanding these interactions between LGB and immune components remains essential for developing hypoallergenic milk products.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
See full target information LGB
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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Immunology and cell biology 101:625-638 PubMed37157183

2023

The potential of dietary nanoparticles to enhance allergenicity of milk proteins: an in vitro investigation.

Applications

Unspecified application

Species

Unspecified reactive species

Ke Xu,Wut Hmone Phue,Niladri Basu,Saji George

Development (Cambridge, England) 149: PubMed35297994

2022

Establishment and characterization of equine mammary organoids using a method translatable to other non-traditional model species.

Applications

Unspecified application

Species

Unspecified reactive species

Arianna P Bartlett,Rebecca M Harman,Jennifer R Weiss,Gerlinde R Van de Walle

Molecular nutrition & food research 65:e2000834 PubMed33559978

2021

Enhanced Uptake of Processed Bovine β-Lactoglobulin by Antigen Presenting Cells: Identification of Receptors and Implications for Allergenicity.

Applications

Unspecified application

Species

Unspecified reactive species

Malgorzata Teodorowicz,Hannah E Zenker,Arifa Ewaz,Theodoros Tsallis,Andreas Mauser,Sabrina Gensberger-Reigl,Nicolette W de Jong,Kasper A Hettinga,Harry J Wichers,R J Joost van Neerven,Huub F J Savelkoul

Journal of bioscience and bioengineering 130:374-381 PubMed32713812

2020

Peptide array-based inhibition ELISA for evaluating antigenicity in infant formulas.

Applications

Unspecified application

Species

Unspecified reactive species

Chisato Kubo,Masaki Kurimoto,Masayoshi Tanaka,Hiroshi Ochi,Fumiaki Abe,Mina Okochi

Journal of proteome research 17:2412-2420 PubMed29851351

2018

Proteomics in Forensic Sciences: Identification of the Nature of the Last Meal at Autopsy.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Pieri,Antonio Lombardi,Pascale Basilicata,Gianfranco Mamone,Gianluca Picariello

Scientific reports 8:5378 PubMed29599438

2018

The secretome from bovine mammosphere-derived cells (MDC) promotes angiogenesis, epithelial cell migration, and contains factors associated with defense and immunity.

Applications

ICC/IF

Species

Cow

Melissa M Ledet,Amy K Vasquez,Gat Rauner,Allison A Bichoupan,Paolo Moroni,Daryl V Nydam,Gerlinde R Van de Walle

Food & function 7:3402-9 PubMed27396729

2016

Antibody-independent identification of bovine milk-derived peptides in breast-milk.

Applications

Unspecified application

Species

Unspecified reactive species

Gianluca Picariello,Francesco Addeo,Pasquale Ferranti,Rita Nocerino,Lorella Paparo,Annalisa Passariello,David C Dallas,Randall C Robinson,Daniela Barile,Roberto Berni Canani

Science signaling 6:ra109 PubMed24345680

2013

Integration of protein abundance and structure data reveals competition in the ErbB signaling network.

Applications

Unspecified application

Species

Unspecified reactive species

Christina Kiel,Erik Verschueren,Jae-Seong Yang,Luis Serrano

Biosensors & bioelectronics 38:308-13 PubMed22789151

2012

Electrochemical immunosensor for the milk allergen β-lactoglobulin based on electrografting of organic film on graphene modified screen-printed carbon electrodes.

Applications

Unspecified application

Species

Unspecified reactive species

Shimaa Eissa,Chaker Tlili,Lamia L'Hocine,Mohammed Zourob

American journal of veterinary research 40:896-8 PubMed112893

1979

Evaluation of the enzyme-linked immunosorbent assay for detecting Brucella abortus antibodies.

Applications

ICC/IF

Species

Unspecified reactive species

J W Byrd,F C Heck,R J Hidalgo
View all publications
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Product promise

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