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AB234809

Anti-LHFPL5 antibody

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(1 Publication)

Rabbit Polyclonal LHFPL5 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LHFPL5 aa 1-100.

View Alternative Names

TMHS, LHFPL5, LHFPL tetraspan subfamily member 5 protein, Lipoma HMGIC fusion partner-like 5 protein, Tetraspan membrane protein of hair cell stereocilia

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LHFPL5 antibody (AB234809)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LHFPL5 antibody (AB234809)

Paraffin-embedded human skeletal muscle tissue stained for LHFPL5 using ab234809 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-LHFPL5 antibody (AB234809)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-LHFPL5 antibody (AB234809)

A549 (Human lung carcinoma cell line) cells labeling LHFPL5 using ab234809 at 1/100 dilution in ICC/IF, followed by an Alexa Fluor® 488-conjugated goat anti-rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LHFPL5 antibody (AB234809)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LHFPL5 antibody (AB234809)

Paraffin-embedded human testis tissue stained for LHFPL5 using ab234809 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LHFPL5 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q8TAF8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LHFPL5 also known as TMHS (Tetraspan Membrane Protein of the Hair Cell Stereocilia) functions mechanically as a component of mechanotransduction in hair cells. This protein has an estimated mass of around 25 kDa and is mainly expressed in the inner ear's cochlear and vestibular systems. It resides in the stereocilia of hair cells where it plays an important role in auditory systems through its association with mechanotransduction channels.
Biological function summary

LHFPL5 contributes to auditory transduction by interacting with other proteins in a complex critical for hair cell function. This complex is involved in converting mechanical stimuli into neural signals. LHFPL5 supports the integrity and function of the mechanotransduction channel allowing the inner ear to detect sound and balance changes. The protein acts as a molecular anchor directly influencing the gating of the channel and overall sensory capabilities.

Pathways

LHFPL5 integrates into the auditory mechanotransduction pathway necessary for hearing. It works in conjunction with proteins such as protocadherin 15 (PCDH15) and myosin 7a which are vital for the linking of molecular structures within the stereocilia. These interactions contribute to the pathway's role in enabling the propagation of electrical signals generated from mechanical excitation fundamental to auditory perception.

Mutations in LHFPL5 are linked to Usher syndrome which causes deafness and progressive vision loss. Additionally its dysfunction is associated with non-syndromic hearing loss. These conditions often involve abnormal interactions with other implicated proteins such as cadherin 23 (CDH23) highlighting the interconnected nature of LHFPL5 within the structural and functional frameworks essential for normal hearing and balance.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Auxiliary subunit of the mechanotransducer (MET) non-specific cation channel complex located at the tips of the shorter stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. Functionally couples PCDH15 to the transduction channel.
See full target information LHFPL5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

World journal of surgical oncology 19:75 PubMed33715625

2021

Circ-KIAA0907 inhibits the progression of oral squamous cell carcinoma by regulating the miR-96-5p/UNC13C axis.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjie Dong,Lei Zhao,Shiyang Zhang,Shijie Zhang,Hongyun Si
View all publications
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Product promise

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