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AB127545

Anti-LHX5 antibody

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(1 Publication)

Rabbit Polyclonal LHX5 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LHX5 aa 50-300.

View Alternative Names

LIM/homeobox protein Lhx5, LIM homeobox protein 5, LHX5

1 Images
Western blot - Anti-LHX5 antibody (AB127545)
  • WB

Unknown

Western blot - Anti-LHX5 antibody (AB127545)

10% SDS PAGE

All lanes:

Western blot - Anti-LHX5 antibody (ab127545) at 1/1000 dilution

All lanes:

A431 whole cell lysate at 30 µg

Predicted band size: 38 kDa,39 kDa,44 kDa,49 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human LHX5 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.

Q9H2C1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LHX5 also known as LIM Homeobox 5 is a transcription factor with a molecular mass of approximately 45 kDa. It plays an important role in regulating gene expression by binding to DNA sequences. This protein is mainly expressed in the central nervous system particularly in the developing brain and spinal cord where it influences neuronal differentiation and development.
Biological function summary

LHX5 contributes significantly to the development of the forebrain and hippocampus. It forms part of a molecular complex that controls the transcription of genes necessary for proper neuronal placement and differentiation. Through its interaction with co-factors LHX5 modulates the expression of downstream target genes involved in neurogenesis.

Pathways

LHX5 plays a role in Wnt signaling and neurodevelopmental pathways. It interacts with other proteins such as LHX1 and LHX2 helping to fine-tune the expression of genes involved in brain patterning and neural circuit formation. These interactions influence critical developmental processes ensuring appropriate neural network establishment.

LHX5 is linked to neurological conditions such as epilepsy and intellectual disability. Mutations or dysregulation in LHX5 may contribute to abnormal neural development leading to these disorders. Additionally LHX5 interacts with other proteins implicated in these conditions such as PAX6 potentially affecting the severity or outcome of the disease state.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.
See full target information LHX5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Investigative ophthalmology & visual science 62:22 PubMed34156427

2021

Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaofen Jin,Juanjuan Zhang,Qiuzi Yi,Feilong Meng,Jialing Yu,Yanchun Ji,Jun Q Mo,Yi Tong,Pingping Jiang,Min-Xin Guan
View all publications
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Product promise

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