AB187975

Anti-LHX5 antibody

Name: Anti-LHX5 antibody (ab187975) | Abcam
Brand: Abcam Limited
SKU: AB187975
Price: 630 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal LHX5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LHX5 aa 100-200.

View Alternative Names

LIM/homeobox protein Lhx5, LIM homeobox protein 5, LHX5

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LHX5 antibody (AB187975)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LHX5 antibody (AB187975)

Immunohistochemical analysis of paraffin embedded Human cerebral cortex tissue labeling LHX5 with ab187975 at 1/10 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human LHX5 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q9H2C1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/20", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

LHX5 also known as LIM Homeobox 5 is a transcription factor with a molecular mass of approximately 45 kDa. It plays an important role in regulating gene expression by binding to DNA sequences. This protein is mainly expressed in the central nervous system particularly in the developing brain and spinal cord where it influences neuronal differentiation and development.

Biological function summary

LHX5 contributes significantly to the development of the forebrain and hippocampus. It forms part of a molecular complex that controls the transcription of genes necessary for proper neuronal placement and differentiation. Through its interaction with co-factors LHX5 modulates the expression of downstream target genes involved in neurogenesis.

Pathways

LHX5 plays a role in Wnt signaling and neurodevelopmental pathways. It interacts with other proteins such as LHX1 and LHX2 helping to fine-tune the expression of genes involved in brain patterning and neural circuit formation. These interactions influence critical developmental processes ensuring appropriate neural network establishment.

LHX5 is linked to neurological conditions such as epilepsy and intellectual disability. Mutations or dysregulation in LHX5 may contribute to abnormal neural development leading to these disorders. Additionally LHX5 interacts with other proteins implicated in these conditions such as PAX6 potentially affecting the severity or outcome of the disease state.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.

See full target information LHX5

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 14:26 PubMed36639679

2023

SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm.

Applications

Unspecified application

Species

Unspecified reactive species

Zhan Yang,Ya-Xuan Wang,Jin-Kun Wen,Hai-Tao Gao,Zhen-Wei Han,Jin-Chun Qi,Jun-Fei Gu,Chen-Ming Zhao,Hong Zhang,Bei Shi,Dan-Dan Wang,Xiao-Lu Wang,Chang-Bao Qu

Bioengineered 12:3188-3200 PubMed34238116

2021

Identification of key genes involved in the recurrence of glioblastoma multiforme using weighted gene co-expression network analysis and differential expression analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Ren,JingYa Wang,Lei Li,XiaoWan Lin,GuangHan Wu,JiaYi Chen,ZhiRui Zeng,HongMei Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-LHX5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LHX5 antibody (AB187975)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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